利用基因驱动控制疟疾传播的蚊子。
Control of malaria-transmitting mosquitoes using gene drives.
机构信息
Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2021 Feb 15;376(1818):20190803. doi: 10.1098/rstb.2019.0803. Epub 2020 Dec 28.
Abstract
Gene drives are selfish genetic elements that can be re-designed to invade a population and they hold tremendous potential for the control of mosquitoes that transmit disease. Much progress has been made recently in demonstrating proof of principle for gene drives able to suppress populations of malarial mosquitoes, or to make them refractory to the parasites they transmit. This has been achieved using CRISPR-based gene drives. In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.
摘要
基因驱动是自私的遗传因子，可以被重新设计来入侵一个种群，它们在控制传播疾病的蚊子方面具有巨大的潜力。最近，在展示能够抑制疟蚊种群或使它们对传播的寄生虫产生抗性的基因驱动的原理证明方面取得了很大进展。这是利用基于 CRISPR 的基因驱动实现的。在本文中，我将讨论这种类型的基因驱动的相对优点，以及其技术发展和作为疟疾控制手段在实地部署的障碍。本文是“蚊媒疾病的新控制策略”主题的一部分。
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Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes.丰富的保守 CRISPR-Cas9 靶位存在于高度多态的疟蚊和伊蚊基因组中。
Nat Commun. 2020 Mar 18;11(1):1425. doi: 10.1038/s41467-020-15204-0.
3
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