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1
Control of malaria-transmitting mosquitoes using gene drives.利用基因驱动控制疟疾传播的蚊子。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb 15;376(1818):20190803. doi: 10.1098/rstb.2019.0803. Epub 2020 Dec 28.
2
Transforming malaria prevention and control: the prospects and challenges of gene drive technology for mosquito management.转化疟疾防控：蚊媒管理中基因驱动技术的前景与挑战。
Ann Med. 2023;55(2):2302504. doi: 10.1080/07853890.2024.2302504. Epub 2024 Jan 17.
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Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility.利用 CRISPR-Cas9 基因驱动抑制疟疾传播媒介以降低雌性生育率的建模。
BMC Biol. 2020 Aug 11;18(1):98. doi: 10.1186/s12915-020-00834-z.
4
Differential attraction in mosquito-human interactions and implications for disease control.蚊虫与人类相互作用中的差异吸引力及其对疾病控制的意义。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb 15;376(1818):20190811. doi: 10.1098/rstb.2019.0811. Epub 2020 Dec 28.
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Novel control strategies for mosquito-borne diseases.新型蚊虫传播疾病控制策略。
Philos Trans R Soc Lond B Biol Sci. 2021 Feb 15;376(1818):20190802. doi: 10.1098/rstb.2019.0802. Epub 2020 Dec 28.
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Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement.将疟蚊的内源性基因转化为简单的非自主基因驱动，以进行种群替换。
Elife. 2021 Apr 13;10:e58791. doi: 10.7554/eLife.58791.
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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.用于疟蚊斯氏按蚊种群修饰的高效Cas9介导的基因驱动
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6736-43. doi: 10.1073/pnas.1521077112. Epub 2015 Nov 23.
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Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group.作为消除撒哈拉以南非洲疟疾的潜在生物控制工具，基因驱动蚊子的部署途径：科学工作组的建议。
Am J Trop Med Hyg. 2018 Jun;98(6_Suppl):1-49. doi: 10.4269/ajtmh.18-0083.
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Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance.乌干达利益攸关方对基因驱动蚊子控制疟疾的希望和担忧：基因驱动风险治理的新方向。
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CRISPR-Accelerated Gene Drives Pump the Brakes.CRISPR加速基因驱动踩下刹车。
CRISPR J. 2019 Aug;2:196-198. doi: 10.1089/crispr.2019.29069.jlm.

引用本文的文献

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The Spatial Spread and the Persistence of Gene Drives Are Affected by Demographic Feedbacks, Density Dependence and Allee Effects.基因驱动的空间传播和持久性受到人口统计学反馈、密度依赖性和阿利效应的影响。
Mol Ecol. 2025 Aug;34(16):e70028. doi: 10.1111/mec.70028. Epub 2025 Jul 19.
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Knowledge, Perspectives, and Risks Perceptions on Gene Drive and Genetically Modified Mosquitoes for Malaria Control among African Stakeholders: A Scoping Review Protocol.非洲利益相关者对用于疟疾控制的基因驱动和转基因蚊子的知识、观点及风险认知：一项范围综述方案
Res Sq. 2025 Jul 9:rs.3.rs-6048767. doi: 10.21203/rs.3.rs-6048767/v1.
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On the use of generative models for evolutionary inference of malaria vectors from genomic data.关于使用生成模型从基因组数据进行疟疾病媒进化推断的研究
bioRxiv. 2025 Jun 27:2025.06.26.661760. doi: 10.1101/2025.06.26.661760.
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Genomic evidence of spatially structured gene flow and divergent insecticide resistance backgrounds of the malaria vector Anopheles funestus in Tanzania.坦桑尼亚疟蚊媒介冈比亚按蚊空间结构化基因流动和不同杀虫剂抗性背景的基因组证据。
Genetics. 2025 Aug 6;230(4). doi: 10.1093/genetics/iyaf117.
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CRISPR/Cas genome editing, functional genomics, and diagnostics for parasitic helminths.用于寄生蠕虫的CRISPR/Cas基因组编辑、功能基因组学及诊断方法
Int J Parasitol. 2025 May 19. doi: 10.1016/j.ijpara.2025.05.001.
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The expanded immunoregulatory protease network in mosquitoes is governed by gene coexpression.蚊子中扩展的免疫调节蛋白酶网络受基因共表达调控。
Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2425863122. doi: 10.1073/pnas.2425863122. Epub 2025 Apr 30.
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A self-limiting sterile insect technique alternative for Ceratitis capitata.一种用于地中海实蝇的自限性不育昆虫技术替代方法。
BMC Biol. 2025 Apr 12;23(1):97. doi: 10.1186/s12915-025-02201-2.
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Genomic diversity of the African malaria vector .非洲疟疾媒介的基因组多样性
bioRxiv. 2024 Dec 17:2024.12.14.628470. doi: 10.1101/2024.12.14.628470.
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Gene drives: an alternative approach to malaria control?基因驱动：控制疟疾的另一种方法？
Gene Ther. 2025 Jan;32(1):25-37. doi: 10.1038/s41434-024-00468-8. Epub 2024 Jul 22.
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The expanded immunoregulatory protease network in mosquitoes is governed by gene co-expression.蚊子中扩展的免疫调节蛋白酶网络受基因共表达调控。
bioRxiv. 2024 Aug 4:2024.06.18.599423. doi: 10.1101/2024.06.18.599423.

本文引用的文献

1
Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance.调控基因驱动的表达是提高其入侵潜力和减轻抗性的关键。
PLoS Genet. 2021 Jan 29;17(1):e1009321. doi: 10.1371/journal.pgen.1009321. eCollection 2021 Jan.
2
Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes.丰富的保守 CRISPR-Cas9 靶位存在于高度多态的疟蚊和伊蚊基因组中。
Nat Commun. 2020 Mar 18;11(1):1425. doi: 10.1038/s41467-020-15204-0.
3
Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing.推进基因驱动改良蚊子进行田间试验的功效和安全标准的定义。
Vector Borne Zoonotic Dis. 2020 Apr;20(4):237-251. doi: 10.1089/vbz.2019.2606. Epub 2020 Mar 9.
4
Cas9-Mediated Gene-Editing in the Malaria Mosquito by ReMOT Control.通过远程控制在疟疾蚊子中进行Cas9介导的基因编辑
G3 (Bethesda). 2020 Apr 9;10(4):1353-1360. doi: 10.1534/g3.120.401133.
5
Development of a confinable gene drive system in the human disease vector .在人类疾病载体中开发一种可限制的基因驱动系统。
Elife. 2020 Jan 21;9:e51701. doi: 10.7554/eLife.51701.
6
A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment.互补基因驱动提供了一个灵活的实验室研究和潜在野外部署的平台。
Nat Commun. 2020 Jan 17;11(1):352. doi: 10.1038/s41467-019-13977-7.
7
Assessment of a Split Homing Based Gene Drive for Efficient Knockout of Multiple Genes.基于分裂同源的基因驱动高效敲除多个基因的评估。
G3 (Bethesda). 2020 Feb 6;10(2):827-837. doi: 10.1534/g3.119.400985.
8
Experimental population modification of the malaria vector mosquito, Anopheles stephensi.实验性改变疟疾传播媒介按蚊，斯蒂芬斯氏按蚊。
PLoS Genet. 2019 Dec 19;15(12):e1008440. doi: 10.1371/journal.pgen.1008440. eCollection 2019 Dec.
9
Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies.在病媒种群替代策略中，效应基因设计与病原体进化之间的拔河比赛中获胜
Front Genet. 2019 Oct 30;10:1072. doi: 10.3389/fgene.2019.01072. eCollection 2019.
10
Locally Fixed Alleles: A method to localize gene drive to island populations.本地化固定等位基因：一种将基因驱动定位到岛屿种群的方法。
Sci Rep. 2019 Nov 1;9(1):15821. doi: 10.1038/s41598-019-51994-0.

利用基因驱动控制疟疾传播的蚊子。

Control of malaria-transmitting mosquitoes using gene drives.

机构信息

Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2021 Feb 15;376(1818):20190803. doi: 10.1098/rstb.2019.0803. Epub 2020 Dec 28.

DOI:10.1098/rstb.2019.0803
PMID:33357060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7776936/
Abstract

Gene drives are selfish genetic elements that can be re-designed to invade a population and they hold tremendous potential for the control of mosquitoes that transmit disease. Much progress has been made recently in demonstrating proof of principle for gene drives able to suppress populations of malarial mosquitoes, or to make them refractory to the parasites they transmit. This has been achieved using CRISPR-based gene drives. In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.

摘要

基因驱动是自私的遗传因子，可以被重新设计来入侵一个种群，它们在控制传播疾病的蚊子方面具有巨大的潜力。最近，在展示能够抑制疟蚊种群或使它们对传播的寄生虫产生抗性的基因驱动的原理证明方面取得了很大进展。这是利用基于 CRISPR 的基因驱动实现的。在本文中，我将讨论这种类型的基因驱动的相对优点，以及其技术发展和作为疟疾控制手段在实地部署的障碍。本文是“蚊媒疾病的新控制策略”主题的一部分。