Mineshige Takayuki, Inoue Takashi, Yurimoto Terumi, Sato Kenya, Kawai Kenji, Sasaki Erika
Division of Advanced Physiology, Central Institute for Experimental Medicine and Life Science, Kawasaki, Japan.
School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Front Vet Sci. 2025 Jul 2;12:1548757. doi: 10.3389/fvets.2025.1548757. eCollection 2025.
Common marmosets () are increasingly being used in neuroscience and biomedical research due to their small size, and ease of handling. Despite their growing research importance, marmoset colonies face health management challenges. Marmoset wasting syndrome (MWS), marmoset duodenal dilatation syndrome (DDS), and -associated disease (CDAD) are the leading causes of mortality in marmosets. We retrospectively analyzed the necropsy records of 192 marmosets based on clinical and pathological criteria at the Central Institute for Medicine and Life Science between 2017 and 2020 to determine the incidence of major diseases and associated treatment modalities. MWS is prevalent in older animals and is characterized by progressive weight loss, hypoalbuminemia, and chronic enteritis. DDS, identified in younger marmosets, is associated with gastrointestinal distress and requires a specialized liquid diet and supportive care. CDAD, which is often triggered by antibiotic administration, leads to sudden death in approximately 68% of cases. This study underscores the need for tailored veterinary care, including early diagnosis, nutritional management, and cautious antibiotic use, to improve marmoset health and reduce mortality rates. Further research on the pathogenesis of these diseases, including gut microbiota analysis, histopathological examination, and diagnostic imaging, is essential for developing effective prevention and treatment strategies.
普通狨猴（）因其体型小且易于处理，在神经科学和生物医学研究中的使用越来越多。尽管它们在研究中的重要性日益增加，但狨猴群体面临着健康管理挑战。狨猴消瘦综合征（MWS）、狨猴十二指肠扩张综合征（DDS）和艰难梭菌相关性疾病（CDAD）是狨猴死亡的主要原因。我们回顾性分析了2017年至2020年期间中央医学与生命科学研究所192只狨猴的尸检记录，根据临床和病理标准确定主要疾病的发病率及相关治疗方式。MWS在老年动物中普遍存在，其特征为进行性体重减轻、低白蛋白血症和慢性肠炎。DDS在较年轻的狨猴中出现，与胃肠道不适有关，需要特殊的流食饮食和支持性护理。CDAD通常由抗生素使用引发，约68%的病例会导致猝死。本研究强调需要有针对性的兽医护理，包括早期诊断、营养管理和谨慎使用抗生素，以改善狨猴健康状况并降低死亡率。对这些疾病的发病机制进行进一步研究，包括肠道微生物群分析、组织病理学检查和诊断成像，对于制定有效的预防和治疗策略至关重要。
