Liu Derrick, Cook Iii Bernard L, Farris Edmund P
Frank H. Netter MD School of Medicine, Quinnipiac University, North Haven, CT, USA.
Department of Immunology, UConn Health, Farmington, CT, USA.
Clin Ophthalmol. 2025 Jul 12;19:2229-2238. doi: 10.2147/OPTH.S530620. eCollection 2025.
The purpose of this study was to evaluate if a short period of playing video games on a personal computer (PC) causes changes in measurements of dry eye disease (DED).
We recruited 41 Quinnipiac University students (ages 18-23 years, mean age 19.66±1.09 years; 9 females, 32 males), with eligibility criteria being 18+ years old, identifying as "gamers" without previous history of eye surgery, steroid use, autoimmune disorders, or history of or previous treatment for dry eye. Each student was administered DED-related assessments before/after four hours of continuous PC gaming: 1) Standardized Patient Evaluation of Eye Dryness (SPEED) and Ocular Surface Disease Index (OSDI) questionnaires, 2) Snellen visual acuity test, 3) tear osmolarity point-of-care assay, 4) matrix metalloproteinase-9 (MMP-9) inflammation point-of-care assay, and 5) an unanesthetized Schirmer test of tear production. Students were limited to 500 cc of water during the four hour period.
Following gaming, the mean SPEED scores increased significantly (p<0.001, Wilcoxon signed-rank test), as did the frequency and severity of soreness/irritation and eye fatigue. Tear osmolarity decreased and tear production increased in the right eye. Other metrics (OSDI, Snellen, and MMP-9) did not change significantly.
As little as four hours of continuous PC gaming with limited hydration results in an increase in self-reported measures of DED symptoms. These prospective findings corroborate the epidemiological link between gaming and DED symptoms and highlight the need for long-term studies.
本研究旨在评估在个人电脑（PC）上短时间玩电子游戏是否会导致干眼病（DED）测量指标的变化。
我们招募了41名昆尼皮亚克大学的学生（年龄18 - 23岁，平均年龄19.66±1.09岁；9名女性，32名男性），入选标准为年龄18岁以上，自认为是“游戏玩家”，且无前眼部手术史、未使用过类固醇、无自身免疫性疾病，也无干眼病史或既往治疗史。每位学生在连续进行4小时电脑游戏前后均接受了与DED相关的评估：1）干眼标准患者评估（SPEED）和眼表疾病指数（OSDI）问卷；2）斯内伦视力测试；3）泪液渗透压即时检测；4）基质金属蛋白酶-9（MMP-9）炎症即时检测；5）未麻醉状态下的泪液分泌试验。在这4小时期间，学生的饮水量限制在500毫升。
游戏后，平均SPEED评分显著增加（p<0.001，Wilcoxon符号秩检验），酸痛/刺激感和眼疲劳的频率及严重程度也增加。右眼的泪液渗透压降低，泪液分泌增加。其他指标（OSDI、斯内伦视力和MMP-9）无显著变化。
连续4小时的电脑游戏且补水有限，就会导致自我报告的DED症状增加。这些前瞻性研究结果证实了游戏与DED症状之间的流行病学联系，并强调了长期研究的必要性。
