Gayadin Deepa, Prunty McKenna, Fretham Stephanie Jb
Luther College, Decorah, Iowa, United States.
MicroPubl Biol. 2025 Jul 2;2025. doi: 10.17912/micropub.biology.001675. eCollection 2025.
Alcohol use and abuse is a common and prevalent disorder characterized by complex and individually variable physiological effects. demonstrate multiple ethanol-induced behaviors and are an effective model for experimentally isolating environmental and genetic factors underlying the actions of ethanol. Using wild type and dopamine signaling mutant the current study found that ethanol exposure results in dopamine release-dependent swimming induced paralysis and that dopamine influences acute sensitivity to ethanol. Taken together, the findings support a role for dopamine in mediating acute responses to ethanol.
酒精使用与滥用是一种常见且普遍的疾病，其特征为具有复杂且个体差异的生理效应。表现出多种乙醇诱导的行为，是用于实验性分离乙醇作用背后的环境和遗传因素的有效模型。利用野生型和多巴胺信号突变体，当前研究发现乙醇暴露会导致多巴胺释放依赖性游泳诱导性麻痹，且多巴胺会影响对乙醇的急性敏感性。综上所述，这些发现支持多巴胺在介导对乙醇的急性反应中发挥作用。
