Daboussi Selsabil, Saidane Asma, Syrine Abdellatif, Mhamdi Samira, Gargouri Faten, Messaoudi Houssem, Hachicha Saber, Aichaouia Chiraz, Moatemri Zied
Pneumology department, Military Hospital, Tunis, Republic of Tunisia.
University of Medicine, University of Tunis El Manar, Tunis, 1007, Republic of Tunisia.
Respir Med Case Rep. 2025 Apr 15;55:102210. doi: 10.1016/j.rmcr.2025.102210. eCollection 2025.
Hamartochondromas are rare benign lung tumors arising from the mesenchymal cells. The endobronchial location is not common (1.4 %).The symptoms are not specific and misleading mimicking a wide spectrum of diseases (Asthma, COPD, Bronchitis …) resulting in a diagnosis delay. We presented here a case of a 64-year patient who had complained of a persistent non-resolving chronic cough despite symptomatic treatments. The diagnosis of an endobronchial hamartoma was made via a repeat bronchial biopsy. The flexible endoscopy showed a white smooth polypoid mass occluding the lumen of the left laterobasal bronchus. A routine surveillance was initially considered. After a 12-year regular follow-up, he was admitted in our department of Pneumology for a recurrent pneumonia. The chest CT scan showed an endobronchial mass occluding the left laterobasal bronchus associated with an obstructive pneumonia. So, he underwent surgery. This benign neoplasia was totally removed by a segmentectomy. The post-operative macroscopic examination revealed a white, small, smooth, endobronchial mass with lobulated margins. The definitive histological exam showed a mixture of mature cartilage islands, mesenchymal tissue and fat. Therefore, the diagnosis of an endobronchial hamartoma was assessed. He was doing well one week after his hospital discharge. We also highlighted this benign lung tumor main clinical presentations, radiological findings as well as the therapeutic strategies and the outcomes.
错构瘤是一种罕见的起源于间充质细胞的良性肺肿瘤。支气管内定位并不常见（1.4%）。症状不具特异性，容易误诊，可模仿多种疾病（哮喘、慢性阻塞性肺疾病、支气管炎……），导致诊断延迟。我们在此介绍一例64岁患者，尽管接受了对症治疗，但仍主诉持续不愈的慢性咳嗽。通过重复支气管活检确诊为支气管内错构瘤。软性内镜检查显示一个白色光滑的息肉样肿物阻塞了左后基底支气管腔。最初考虑进行常规监测。经过12年的定期随访后，他因复发性肺炎入住我们的呼吸内科。胸部CT扫描显示一个支气管内肿物阻塞左后基底支气管，并伴有阻塞性肺炎。于是，他接受了手术。通过肺段切除术将这个良性肿瘤完全切除。术后大体检查显示一个白色、小、光滑、有分叶边缘的支气管内肿物。最终的组织学检查显示为成熟软骨岛、间充质组织和脂肪的混合物。因此，确诊为支气管内错构瘤。出院一周后他情况良好。我们还强调了这种良性肺肿瘤的主要临床表现、影像学表现以及治疗策略和结果。
