Kiołbasa Martyna, Kaminiów Konrad, Pastuszczak Maciej
Department of Dermatology, Clinical Department of Internal Medicine, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland.
Postepy Dermatol Alergol. 2025 Jan 31;42(3):215-220. doi: 10.5114/ada.2024.147332. eCollection 2025 Jun.
Serofast state is defined as an insufficient decrease in the non-treponemal reaction titre after 6-12 months for early syphilis or after 12-24 months for late syphilis counting from the recommended treatment, with the simultaneous resolution of the infection symptoms.
The aim of this article was to review the current understanding of the serofast state. Additionally, data on recommended diagnostic and therapeutic approaches for patients with serofast state were presented.
In order to review the current understanding in the field of serofast syphilis, the PubMed database was searched.
The available literature relating to serofast syphilis is mainly concerned with predictive factors of the serofast state.
Understanding the predictive factors of the serofast state and its pathomechanism is crucial. This knowledge enables early identification of patients who, following treatment, may require increased clinical supervision and a slightly altered therapeutic management plan.
血清固定状态的定义为，从推荐治疗开始计算，早期梅毒在6 - 12个月后或晚期梅毒在12 - 24个月后，非梅毒螺旋体反应滴度下降不足，同时感染症状消失。
本文旨在综述目前对血清固定状态的认识。此外，还介绍了血清固定状态患者推荐的诊断和治疗方法的数据。
为了综述血清固定梅毒领域的当前认识，检索了PubMed数据库。
与血清固定梅毒相关的现有文献主要关注血清固定状态的预测因素。
了解血清固定状态的预测因素及其发病机制至关重要。这些知识有助于早期识别那些治疗后可能需要加强临床监测和稍微调整治疗管理计划的患者。
