Ahmed Ammar, Asirvatham Roshini, Ullal Jagdeesh, Moheet Amir
Division of Endocrinology,Diabetes and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
School of Medicine, University of Minnesota, Twin Cities, MN, United States.
J Clin Transl Endocrinol. 2025 Jun 23;41:100403. doi: 10.1016/j.jcte.2025.100403. eCollection 2025 Sep.
Cystic fibrosis-related diabetes (CFRD) is the most prevalent extrapulmonary comorbidity in CF. While insulin remains the standard treatment, increasing rates of overweight and obesity due to CFTR modulators highlight the need for new therapies. SGLT2 inhibitors, effective in type 2 diabetes, have not been studied in CFRD. This case series presents eight CFRD patients treated with SGLT2 inhibitors alongside insulin for one year. Half had BMI reductions (1.33-2.89 kg/m2); others had increases. Glycemic control improved in six, worsened in two due to insulin nonadherence. Insulin adjustments showed no pattern. One patient discontinued due to genital infections; overall tolerance was high.
囊性纤维化相关糖尿病（CFRD）是囊性纤维化（CF）中最常见的肺外合并症。虽然胰岛素仍然是标准治疗方法，但由于CFTR调节剂导致超重和肥胖的发生率不断上升，凸显了对新疗法的需求。钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂对2型糖尿病有效，但尚未在CFRD中进行研究。本病例系列介绍了8例接受SGLT2抑制剂联合胰岛素治疗一年的CFRD患者。一半患者的体重指数（BMI）降低（1.33 - 2.89kg/m²）；其他患者则升高。6例患者的血糖控制得到改善，2例因胰岛素治疗依从性差而恶化。胰岛素调整无规律可循。1例患者因生殖器感染停药；总体耐受性良好。
