Pezzini Julia Valle, Trevisan Dante Diniz, Dominiak Soares Victor Henrique, Gauer Luís Eduardo, Lima Marcelo M S
Neurophysiology Laboratory, Department of Physiology, Biological Sciences Sector, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Sleep Sci. 2024 Oct 23;18(2):e147-e154. doi: 10.1055/s-0044-1791235. eCollection 2025 Jun.
Sleep disturbances are prevalent in Parkinson disease (PD), encompassing a spectrum from parasomnias like REM sleep behavior disorder to symptoms of sleep-wake cycle dysregulation, such as insomnia and daytime sleepiness. This research investigates sleep quality in PD patients compared with a matched healthy control group and explores the relationships between PD clinical characteristics and sleep parameters. Additionally, the study assesses the reliability of the Pittsburgh Sleep Quality Index (PSQI) for PD patients by examining internal consistency. The study comprises 52 participants, 27 in the PD group and 25 in the healthy control group, matched for sex and age. Sleep quality revealed that PD patients experienced significantly poorer sleep quality than the control group ( = 0.009). Weak correlations were found between PSQI scores and the modified Hoehn and Yahr scale ( = 0.062), with no correlation observed with the daily equivalent dose of levodopa (L-DOPA). The prevalence of poor sleep quality (PSQI score > 5) was 85.1% for PD patients and 68% for the control group. The internal consistency analysis of the PSQI yielded a Cronbach's α of 0.588 for the PD group. While the PSQI demonstrates utility in detecting general sleep abnormalities and gauging patient perceptions of sleep quality in PD, its limitation as a global score is emphasized. The index prioritizes sleep habits and may not fully capture important sleep disorders in this population. These findings underscore the complex relationship between PD and sleep quality, suggesting the need for a comprehensive approach to assess and address sleep disturbances in PD patients.
睡眠障碍在帕金森病（PD）中很常见，涵盖从快速眼动睡眠行为障碍等异态睡眠到睡眠-觉醒周期失调症状，如失眠和日间嗜睡等一系列情况。本研究将帕金森病患者的睡眠质量与匹配的健康对照组进行比较，并探讨帕金森病临床特征与睡眠参数之间的关系。此外，该研究通过检查内部一致性来评估匹兹堡睡眠质量指数（PSQI）对帕金森病患者的可靠性。该研究包括52名参与者，帕金森病组27人，健康对照组25人，两组在性别和年龄上相匹配。睡眠质量显示，帕金森病患者的睡眠质量明显比对照组差（P = 0.009）。PSQI评分与改良的 Hoehn 和 Yahr 量表之间存在弱相关性（P = 0.062），与左旋多巴（L-DOPA）的每日等效剂量未观察到相关性。帕金森病患者睡眠质量差（PSQI评分>5）的患病率为85.1%，对照组为68%。PSQI的内部一致性分析得出帕金森病组的Cronbach's α为0.588。虽然PSQI在检测帕金森病患者的一般睡眠异常和衡量患者对睡眠质量的感知方面具有实用性，但强调了其作为整体评分的局限性。该指数优先考虑睡眠习惯，可能无法完全捕捉该人群中重要的睡眠障碍。这些发现强调了帕金森病与睡眠质量之间的复杂关系，表明需要一种综合方法来评估和解决帕金森病患者的睡眠障碍。
