Arinel Minel, Abdelaal Karim
Naumann Laboratory, Department of Neurobiology, Duke University School of Medicine, Durham, NC, United States.
The Collective for Psychiatric Neuroengineering, Department of Neurobiology, Duke University School of Medicine, Durham, NC, United States.
Front Integr Neurosci. 2025 Jul 2;19:1479923. doi: 10.3389/fnint.2025.1479923. eCollection 2025.
Reward processing, which ensures survival, has evolved to also shape emotions, learning, and overall well-being. While traditional models of reward have focused predominantly on central neural circuits, emerging evidence underscores the role of peripheral bodily signals. This represents a new opportunity by which we may understand neurological and neuropsychiatric health. In this review, we explore the gut-brain and heart-brain interfaces in reward processing, delineating their contributions across distinct phases of reward and offering insights into their bioenergetic significance. By framing this interplay within an adaptive and clinical context, we propose new avenues for understanding and treating neuropsychiatric disorders through a mind-body medicine lens.
确保生存的奖赏处理机制在进化过程中也塑造了情绪、学习和整体幸福感。虽然传统的奖赏模型主要关注中枢神经回路，但新出现的证据强调了外周身体信号的作用。这为我们理解神经和神经精神健康提供了一个新机会。在这篇综述中，我们探讨了奖赏处理中的肠-脑和心-脑界面，描述了它们在奖赏不同阶段的作用，并深入了解它们的生物能量学意义。通过在适应性和临床背景下构建这种相互作用，我们提出了通过身心医学视角理解和治疗神经精神疾病的新途径。
