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支气管肺发育不良的发病机制:“问题永远出在肺部,而非心脏”——是谬论还是准则?

The pathogenesis of bronchopulmonary dysplasia: "It is never the heart, it is always the lung" - myth or maxim?

作者信息

Hadchouel Alice, Delacourt Christophe

机构信息

AP-HP, Hôpital Universitaire Necker-Enfants Malades, Service de Pneumologie Pédiatrique, Centre de Référence pour les Maladies Respiratoires Rares de l'Enfant, Paris, France.

Université Paris Cité, Paris, France.

出版信息

Breathe (Sheff). 2025 Jul 15;21(3):240102. doi: 10.1183/20734735.0102-2024. eCollection 2025 Jul.

DOI:10.1183/20734735.0102-2024
PMID:40673065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12260909/
Abstract

"This is not the heart; this is the lung." Who among paediatric pulmonologists has never faced this situation with a cardiologist? Joking aside, discussions for some cases may be tricky and our common ultimate goal is always to provide the best care to the patients and their families. In this review, we will focus on the links between the heart, or more widely the cardiovascular system, and bronchopulmonary dysplasia, in order to determine if this quote is a myth or a maxim.

摘要

“这不是心脏;这是肺。”儿科肺科医生中,谁没有和心脏科医生遇到过这种情况呢?玩笑归玩笑,有些病例的讨论可能很棘手,而我们共同的最终目标始终是为患者及其家人提供最佳护理。在这篇综述中,我们将聚焦于心脏,或者更广泛地说心血管系统,与支气管肺发育不良之间的联系,以确定这句话是无稽之谈还是至理名言。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/488d84f33cdd/EDU-0102-2024.03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/111c6d9b0462/EDU-0102-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/5c18087c9c4f/EDU-0102-2024.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/488d84f33cdd/EDU-0102-2024.03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/111c6d9b0462/EDU-0102-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/5c18087c9c4f/EDU-0102-2024.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c4/12260909/488d84f33cdd/EDU-0102-2024.03.jpg

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本文引用的文献

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Neonatal Risk Factors for Pulmonary Vein Stenosis in Infants Born Preterm with Severe Bronchopulmonary Dysplasia.早产儿重度支气管肺发育不良并发肺静脉狭窄的新生儿危险因素。
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Atrial septal defect closure is associated with improved clinical status in patients ≤ 10 kg with bronchopulmonary dysplasia.房间隔缺损封堵术与体重≤10千克的支气管肺发育不良患者临床状况改善相关。
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Endothelial progenitor cells derived from embryonic stem cells prevent alveolar simplification in a murine model of bronchopulmonary dysplasia.源自胚胎干细胞的内皮祖细胞可预防支气管肺发育不良小鼠模型中的肺泡简化。
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