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Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics.

作者信息

Fiume Monice M, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Peterson Lisa A, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Heldreth Bart

机构信息

Cosmetic Ingredient Review Senior Director.

Expert Panel for Cosmetic Ingredient Safety Member.

出版信息

Int J Toxicol. 2025 Aug;44(2_suppl):103S-123S. doi: 10.1177/10915818251343874. Epub 2025 Jul 17.

DOI:10.1177/10915818251343874
PMID:40673532
Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.

摘要

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