Johnson Wilbur, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Fiume Monice, Heldreth Bart
Cosmetic Ingredient Review Former Scientific Analyst/Writer.
Expert Panel for Cosmetic Ingredient Safety Member.
Int J Toxicol. 2025 Aug;44(2_suppl):38S-53S. doi: 10.1177/10915818251340382. Epub 2025 Jul 17.
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 5 titanium complexes as used in cosmetic products; these ingredients have the following reported functions in cosmetics: surface modifier (Isopropyl Titanium Triisostearate); colorant; humectant (Titanium Citrate); binder (Titanium Ethoxide); film former; opacifying agent (Titanium Isostearates); and preservative (Titanium Salicylate). The Panel reviewed relevant data relating to the safety of these ingredients in cosmetic formulations and issued the following separate conclusions. Isopropyl Titanium Triisostearate is safe in cosmetics in the present practices of use and concentration described in the safety assessment, when used as a surface modifier. The data are insufficient to determine the safety of Titanium Citrate, Titanium Ethoxide, Titanium Isostearates, and Titanium Salicylate.
化妆品成分安全专家小组(小组)审查了化妆品中使用的5种钛络合物的安全性;这些成分在化妆品中具有以下已报道的功能:表面改性剂(三异硬脂酸异丙酯钛);着色剂;保湿剂(柠檬酸钛);粘合剂(乙醇钛);成膜剂;遮光剂(异硬脂酸钛);以及防腐剂(水杨酸钛)。小组审查了与这些成分在化妆品配方中的安全性相关的数据,并发布了以下单独结论。在安全评估中描述的当前使用方法和浓度下,三异硬脂酸异丙酯钛作为表面改性剂在化妆品中使用是安全的。数据不足以确定柠檬酸钛、乙醇钛、异硬脂酸钛和水杨酸钛的安全性。