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勒丹泰克病毒:鉴定为一种与人类感染相关的弹状病毒并形成一个新血清群。

LeDantec virus: identification as a rhabdovirus associated with human infection and formation of a new serogroup.

作者信息

Cropp C B, Prange W C, Monath T P

出版信息

J Gen Virol. 1985 Dec;66 ( Pt 12):2749-54. doi: 10.1099/0022-1317-66-12-2749.

DOI:10.1099/0022-1317-66-12-2749
PMID:4067583
Abstract

LeDantec virus, originally recovered in 1965 from a patient with a febrile illness in Senegal, was observed by thin section electron microscopy to be bullet-shaped, representative of members of the rhabdovirus group, with mean dimensions of 164 X 78 nm. Particles were observed budding from the plasma membrane and moderate numbers accumulated in the intercellular spaces. In three mammalian cell lines, LeDantec virus was rapidly cytopathic and replicated to moderately high titres. In complement fixation tests with other known rhabdoviruses, LeDantec was found to be related to Keuraliba virus, a previously ungrouped agent isolated from rodents in Senegal in 1968. We propose the formation of a new LeDantec serogroup comprising these two viruses.

摘要

勒丹泰克病毒最初于1965年从塞内加尔一名发热患者身上分离出来,通过超薄切片电子显微镜观察到其呈子弹状,是弹状病毒科成员的典型形态,平均尺寸为164×78纳米。观察到病毒粒子从质膜出芽,中等数量的粒子积聚在细胞间隙中。在三种哺乳动物细胞系中,勒丹泰克病毒具有快速致细胞病变的特性,并能复制到中等偏高的滴度。在用其他已知弹状病毒进行的补体结合试验中,发现勒丹泰克病毒与库拉利巴病毒有关,库拉利巴病毒是1968年从塞内加尔啮齿动物中分离出的一种先前未分类的病原体。我们提议组建一个包含这两种病毒的新的勒丹泰克血清群。

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