Shepherd James G, Davis Chris, Streicker Daniel G, Thomson Emma C
Centre for Virus Research, MRC-University of Glasgow, Glasgow G61 1QH, UK.
School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Biology (Basel). 2023 Jun 17;12(6):878. doi: 10.3390/biology12060878.
is a large viral family, with members infecting a diverse range of hosts including, vertebrate species, arthropods, and plants. The predominant human pathogen within the family is , the main cause of human rabies. While rabies is itself a neglected disease, there are other, less well studied, rhabdoviruses known to cause human infection. The increasing application of next-generation sequencing technology to clinical samples has led to the detection of several novel or rarely detected rhabdoviruses associated with febrile illness. Many of these viruses have been detected in low- and middle-income countries where the extent of human infection and the burden of disease remain largely unquantified. This review describes the rhabdoviruses other than that have been associated with human infection. The discovery of the Bas Congo virus and Ekpoma virus is discussed, as is the re-emergence of species such as Le Dantec virus, which has recently been detected in Africa 40 years after its initial isolation. Chandipura virus and the lyssaviruses that are known to cause human rabies are also described. Given their association with human disease, the viruses described in this review should be prioritised for further study.
是一个庞大的病毒家族，其成员可感染多种宿主，包括脊椎动物、节肢动物和植物。该家族中主要的人类病原体是，它是人类狂犬病的主要病因。虽然狂犬病本身是一种被忽视的疾病，但还有其他一些研究较少的弹状病毒已知可导致人类感染。下一代测序技术在临床样本中的应用日益增多，已检测到几种与发热性疾病相关的新型或罕见弹状病毒。这些病毒大多在低收入和中等收入国家被检测到，在这些国家，人类感染的程度和疾病负担在很大程度上仍未得到量化。本综述描述了除之外与人类感染相关的弹状病毒。讨论了巴刚果病毒和埃克波马病毒的发现，以及诸如勒丹泰克病毒等物种的再次出现，该病毒最初分离40年后最近在非洲被检测到。还描述了已知可导致人类狂犬病的钱迪普拉病毒和狂犬病病毒。鉴于它们与人类疾病的关联，本综述中描述的病毒应优先进行进一步研究。
