Ashley D V, Liardon R, Leathwood P D
J Neural Transm. 1985;63(3-4):271-83. doi: 10.1007/BF01252031.
The effect of a carbohydrate, a 20% protein, or a carbohydrate +0.3% tryptophan TRP breakfast on plasma large neutral amino acid ratios was studied in 6 healthy men. The carbohydrate-rich meal produced shifts in plasma amino acid concentrations such that plasma TRP/LNAA ratios increased from 0.13 to 0.15 (p less than 0.04) and the protein meal decreased the ratio from 0.14 to 0.11 (p less than 0.04) after 1 hour. Addition of 0.3% TRP to the carbohydrate-rich meal increased plasma TRP/LNAA ratios more than 2-fold. The TRP containing meal was thus the only one likely to influence brain 5-HT synthesis, although the difference between the plasma TRP/LNAA ratios after carbohydrate and protein breakfasts suggests that the brain may distinguish, by synthesizing more or less 5-HT, the composition of breakfast meals.
在6名健康男性中研究了碳水化合物、20%蛋白质或碳水化合物+0.3%色氨酸（TRP）早餐对血浆中大中性氨基酸比例的影响。富含碳水化合物的餐食会使血浆氨基酸浓度发生变化，使得血浆TRP/LNAA比例在1小时后从0.13增加到0.15（p<0.04），而蛋白质餐食则使该比例从0.14降低到0.11（p<0.04）。向富含碳水化合物的餐食中添加0.3%的TRP可使血浆TRP/LNAA比例增加超过两倍。因此，含TRP的餐食是唯一可能影响大脑5-羟色胺合成的餐食，尽管碳水化合物和蛋白质早餐后血浆TRP/LNAA比例的差异表明，大脑可能通过或多或少地合成5-羟色胺来区分早餐的成分。
