Yuwiler A, Brammer G L, Morley J E, Raleigh M J, Flannery J W, Geller E
Arch Gen Psychiatry. 1981 Jun;38(6):619-26. doi: 10.1001/archpsyc.1981.01780310019001.
Single and repetitive tryptophan loads were consumed by normal, adult male volunteers, and blood concentrations of tryptophan, serotonin, and kynurenine, their time courses, and their distributions within blood were measured. Repeated measures of basal and tryptophan-induced changes in tryptophan and serotonin blood concentrations were characteristic for individual subjects. Tryptophan dose-responsive increases in measured substances returned to basal levels within 24 hours after single tryptophan loads. However, cumulative increases in serotonin concentration in early-morning, predose blood samples were seen following repetitive daily tryptophan administration. Extra-platelet serotonin could be detected in blood samples taken after tryptophan loading and after repetitive daily tryptophan consumption but not in baseline samples taken before short-term loading. Neither platelet number nor size was altered by the loading procedures. Tryptophan loading produced lethargy and drowsiness within 30 minutes of ingestion under all loading conditions. Subjects with the slowest kynurenine response to tryptophan were most behaviorally affected.
正常成年男性志愿者摄入单次及重复的色氨酸负荷，然后测量血液中色氨酸、血清素和犬尿氨酸的浓度、它们的时间进程以及在血液中的分布情况。色氨酸和血清素血液浓度的基础值以及色氨酸诱导的变化的重复测量结果具有个体特征。单次色氨酸负荷后，所测物质中色氨酸剂量反应性增加在24小时内恢复至基础水平。然而，每日重复给予色氨酸后，清晨给药前血样中血清素浓度会出现累积增加。色氨酸负荷后及每日重复摄入色氨酸后采集的血样中可检测到血小板外血清素，但短期负荷前采集的基线样本中未检测到。负荷程序未改变血小板数量和大小。在所有负荷条件下，摄入色氨酸后30分钟内会出现嗜睡和困倦。对色氨酸的犬尿氨酸反应最慢的受试者行为受影响最大。
