Santyr Brendan, Boutet Alexandre, Abbass Mohamad, Vetkas Artur, Germann Jürgen, Ajala Afis, Qiu Jianwei, Elias Gavin J B, Sarica Can, Yang Andrew Z, Alhashyan Ibrahim, Kalia Suneil K, Fasano Alfonso, Lozano Andres M
Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Department of Clinical Neurological Sciences, Western University, London, ON, Canada.
NPJ Parkinsons Dis. 2025 Jul 17;11(1):215. doi: 10.1038/s41531-025-01064-2.
Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson's disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.
对于帕金森病的脑深部刺激而言，单侧植入与双侧植入是关键的手术考量因素；然而，两者不同的治疗效果仍未被完全理解。在主动刺激期间使用功能磁共振成像，我们发现双侧刺激增强了关键运动中枢的激活，同时减少了单侧刺激时出现的非运动反应，且与更好的治疗效果相关。这表明双侧刺激后运动功能改善存在潜在的机制基础。
