Liu Yud Dan, Li Hui Fang, Zhai Ya Xian, Shen Yun Xia, Yang Jinmei, He Li Mei, Shen Ting
School of Nursing, Yunnan University of Traditional Chinese Medicine, Kunming, China.
Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China.
Front Neurol. 2025 Jul 3;16:1598974. doi: 10.3389/fneur.2025.1598974. eCollection 2025.
This study aimed to synthesize and evaluate the best evidence for non-pharmacological interventions targeting mild cognitive impairment in Parkinson's disease (PD-MCI), thereby informing the development of cognitive management strategies for this population.
A systematic search was conducted across multiple databases (e.g., UpToDate, BMJ Best Practice, and Cochrane Library) up to November 2024. Two researchers independently screened literature, assessed quality using standardized tools (AGREE II, JBI criteria), and graded evidence.
Thirteen studies were included (five guidelines, two clinical decisions, two systematic reviews, one meta-analysis, and three RCTs). Twenty evidence points were categorized into six themes: safety/efficacy, assessment, cognitive training, exercise, health education, and multi-strategy approaches.
This study consolidates evidence supporting non-pharmacological interventions for PD-MCI, offering actionable recommendations for clinical practice to delay progression to Parkinson's disease dementia (PDD).
本研究旨在综合并评估针对帕金森病轻度认知障碍（PD-MCI）的非药物干预的最佳证据，从而为该人群的认知管理策略制定提供参考。
截至2024年11月，在多个数据库（如UpToDate、BMJ最佳实践和Cochrane图书馆）中进行了系统检索。两名研究人员独立筛选文献，使用标准化工具（AGREE II、JBI标准）评估质量并对证据进行分级。
纳入了13项研究（5项指南、2项临床决策、2项系统评价、1项荟萃分析和3项随机对照试验）。20个证据点被归类为六个主题：安全性/有效性、评估、认知训练、运动、健康教育和多策略方法。
本研究整合了支持PD-MCI非药物干预的证据，为临床实践提供了可行的建议，以延缓进展为帕金森病痴呆（PDD）。
