German Center of Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
German Center of Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany; Department of Psychology, University of Calgary, 2500 University Dr. NW, Calgary, AB, 2N 1N4, Canada.
Parkinsonism Relat Disord. 2023 Aug;113:105330. doi: 10.1016/j.parkreldis.2023.105330. Epub 2023 Feb 17.
Cognitive impairment in Parkinson's disease (PD), especially in patients with mild cognitive impairment (PD-MCI), coincides with less physical activity. Cognitive trainings (CT) have been found to promote laboratory environment-based movement. Knowledge about their effect in natural home-based environment, reflecting everyday function, is sparse. This explorative study investigated short-term effects of CT on physical activity assessed by home-based accelerometry, and its relation to change of cognitive function over time and non-cognitive outcomes in patients with PD-MCI. Cognitive and non-cognitive correlates of movement parameters at pretest were evaluated as well.
Eighteen patients with PD-MCI of the TrainParC study were analyzed. Those patients received either a 6-week multidomain group CT or physical training (PT). Physical activity and sedentary behavior were assessed with wearable accelerometers worn up to seven days pre- and post-training.
Patients in the CT group displayed significantly greater increases in active periods after training than patients assigned to PT. In the CT group, increases in executive functioning were associated with increases in active periods and decreases in active mean bout length after training. At pretest, reduced working memory correlated with longer sedentary mean bout length, and impairment in activities of daily living (ADL) correlated with a higher number of sedentary periods.
Study data revealed that CT can increase physical activity in patients with PD-MCI, possibly due to effects on executive functions, which needs further investigation in larger sample sizes. Lower working memory performance and ADL impairment might be associated with a more inactive lifestyle in patients with PD-MCI.
帕金森病（PD）患者认知障碍，尤其是轻度认知障碍（PD-MCI）患者，与较少的身体活动有关。认知训练（CT）已被发现可促进实验室环境中的运动。但关于其在自然家庭环境中的影响，反映日常功能的知识还很匮乏。本探索性研究调查了 CT 对基于家庭的加速度计评估的身体活动的短期影响，及其与 PD-MCI 患者认知功能随时间的变化以及非认知结果的关系。还评估了运动参数与认知和非认知相关性在测试前的表现。
分析了 TrainParC 研究中的 18 名 PD-MCI 患者。这些患者接受了 6 周的多领域小组 CT 或物理训练（PT）。使用可穿戴式加速度计在训练前和训练后佩戴长达 7 天，评估身体活动和久坐行为。
与接受 PT 的患者相比，接受 CT 治疗的患者在训练后主动时间段显著增加。在 CT 组中，执行功能的提高与训练后主动时间段的增加和主动平均回合长度的减少相关。在测试前，工作记忆减少与较长的久坐平均回合长度相关，而日常生活活动（ADL）受损与更多的久坐时间段相关。
研究数据显示，CT 可以增加 PD-MCI 患者的身体活动，这可能是由于对执行功能的影响，需要在更大的样本量中进一步研究。较低的工作记忆表现和 ADL 受损可能与 PD-MCI 患者的生活方式不活跃有关。
