Wang Yuhong, Li Weichao, Dong Tingting, Xu Rui, Ai Qing, Yang Lili, Gai Xuesong, Li Li
Department of Rehabilitation Medicine, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Department of Orthopedics, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Front Hum Neurosci. 2025 Jul 3;19:1601651. doi: 10.3389/fnhum.2025.1601651. eCollection 2025.
Sarcopenia and cognitive impairment (CI) are major contributors to disability among the elderly, diminishing their quality of life and placing also a significant burden on healthcare systems and societies. There are currently no effective treatments for sarcopenia and CI. Interestingly, recent research has revealed a strong connection between these two conditions. Although the exact mechanisms of this relationship remain unclear, factors such as chronic inflammation, mitochondrial oxidative stress, and impaired communication through the muscle-brain axis have been put forward. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can modulate neural plasticity and reduce inflammation and oxidative stress, demonstrating considerable potential for improving CI and motor function disorders. In this review, we summarize the relationship between sarcopenia and CI and discuss their shared mechanisms of action. In addition, we aim to provide new research insights and treatment directions by describing the physiopathological mechanisms modulated by TMS and its therapeutic potential for treating CI and sarcopenia.
肌肉减少症和认知障碍是老年人残疾的主要原因，降低了他们的生活质量，也给医疗系统和社会带来了沉重负担。目前尚无针对肌肉减少症和认知障碍的有效治疗方法。有趣的是，最近的研究揭示了这两种病症之间的紧密联系。尽管这种关系的确切机制尚不清楚，但诸如慢性炎症、线粒体氧化应激以及通过肌肉-脑轴的通讯受损等因素已被提出。经颅磁刺激（TMS）是一种非侵入性脑刺激技术，可调节神经可塑性并减轻炎症和氧化应激，在改善认知障碍和运动功能障碍方面显示出巨大潜力。在本综述中，我们总结了肌肉减少症和认知障碍之间的关系，并讨论了它们共同的作用机制。此外，我们旨在通过描述经颅磁刺激调节的生理病理机制及其治疗认知障碍和肌肉减少症的治疗潜力，提供新的研究见解和治疗方向。
