Zhang Liangchuan, Peng Yating, Kong Yuan, Zhang Xue, Li Zetian, Jia Hong
School of Public Health, Southwest Medical University, Luzhou City, Sichuan Province, China.
Collaborating Center of the National Institute of Health Data Sciences of China, Southwest Medical University, Luzhou, Sichuan Province, China.
Eur Geriatr Med. 2025 Feb;16(1):5-13. doi: 10.1007/s41999-024-01097-5. Epub 2024 Nov 19.
During the aging process, a decrease in irisin levels is associated with numerous bone and muscle diseases. This study aims to provide evidence of circulating irisin levels in patients with sarcopenia.
This systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard and the recommendations of the Cochrane Collaboration. A comprehensive search was conducted in PubMed, Embase, Web of Science databases, and other sources from their establishment until August 2023. The Review Manager software version 5.4 was used to calculate the standard mean difference (SMD). I statistics measured heterogeneity.
12 studies involving 2133 participants who met the inclusion criteria were analyzed. We found that irisin levels were significantly lower in patients with sarcopenia (SMD: - 1.28; 95% CI - 1.65, - 0.90; I = 92% P < 0.001). Sensitivity analysis confirmed the robustness of this result. The correlation results showed that there was a positive correlation between the levels of circulating irisin and muscle mass (r value 0.62, 95% CI 0.31, 0.81; P < 0.001) and strength (r value 0.47, 95% CI 0.23, 0.66; P < 0.001), but no statistical correlation between irisin and muscle function (The P-values for gait speed and chair test time are 0.5523 and 0.1467, respectively).
No matter the study area, study design, blood samples, or diagnostic criteria, the concentration of circulating irisin in patients with sarcopenia was lower than that in the control group.
在衰老过程中，鸢尾素水平降低与多种骨骼和肌肉疾病相关。本研究旨在提供肌肉减少症患者循环鸢尾素水平的证据。
本系统评价基于系统评价和Meta分析的首选报告项目（PRISMA）标准以及Cochrane协作网的建议进行。对PubMed、Embase、Web of Science数据库以及其他来源从建库至2023年8月进行了全面检索。使用Review Manager软件5.4版计算标准均数差（SMD）。I统计量测量异质性。
分析了12项研究，共2133名符合纳入标准的参与者。我们发现，肌肉减少症患者的鸢尾素水平显著较低（SMD：-1.28；95%CI -1.65，-0.90；I = 92%，P < 0.001）。敏感性分析证实了该结果的稳健性。相关性结果表明，循环鸢尾素水平与肌肉量（r值0.62，95%CI 0.31，0.8-1；P < 0.001）和力量（r值0.47，95%CI 0.23，0.66；P < 0.001）之间存在正相关，但鸢尾素与肌肉功能之间无统计学相关性（步态速度和椅子试验时间的P值分别为0.5523和0.1467）。
无论研究地区、研究设计、血样或诊断标准如何，肌肉减少症患者循环鸢尾素的浓度均低于对照组。
