This literature review provides a comprehensive overview of the use of complementary and alternative modalities for the treatment of autoimmune diseases, which pose a significant challenge in contemporary healthcare, often requiring long-term management with conventional therapies. It explores a diverse range of complementary and alternative therapies, including herbal remedies, dietary interventions, mind-body practices, and emerging therapies, in the context of the management of several autoimmune diseases, highlighting increased patient satisfaction, pain management and adaptation. The findings shed light on the evolving role of complementary and alternative medicine in addressing autoimmune diseases, emphasizing the importance of a holistic approach to patient care.