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鼻腔黏膜定植的野生型实现广谱病毒清除

Broad-Spectrum Virus Elimination by Nasal Mucosa-Colonized Wild-Type .

作者信息

Li Yuchen, Yang Chengjie, Tang Rongfeng, Wang Chengcheng, Li Yunfeng, Chao Wenwen, Cui Ahui, Liang Chun, Duan Ying, Zeng Hui, Yang Qian

机构信息

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.

出版信息

Research (Wash D C). 2025 Jul 17;8:0781. doi: 10.34133/research.0781. eCollection 2025.

DOI:10.34133/research.0781
PMID:40678151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12270477/
Abstract

Outbreaks and the widespread prevalence of porcine respiratory infectious diseases have led to substantial economic losses worldwide. In this study, epidemiological surveillance revealed lower viral detection in association with an increased abundance of in pigs with outdoor access; thus, NS12, a strain with enhanced mucosal colonization and superior broad-spectrum antiviral activity, was isolated from the nasal mucosa of these pigs for further investigation. This mechanistic study revealed that the antiviral efficacy of NS12 is primarily attributed to bioactive metabolites, including a novel surfactin with high safety and antiviral activity and piceatannol, a potent antioxidant molecule. These metabolites modify the structure and fluidity of phospholipids within the viral envelope, thereby inhibiting viral entry by impeding membrane fusion. Therefore, with its broad-spectrum antiviral activity, NS12 offers a probiotic-based, environmentally sustainable, and noninvasive antiviral strategy for preventing and controlling respiratory viral infections.

摘要

猪呼吸道传染病的暴发和广泛流行已在全球范围内造成了巨大的经济损失。在本研究中，流行病学监测显示，户外饲养的猪病毒检测率较低，同时某种物质的丰度增加；因此，从这些猪的鼻黏膜中分离出具有增强黏膜定植能力和卓越广谱抗病毒活性的NS12菌株进行进一步研究。这项机制研究表明，NS12的抗病毒功效主要归因于生物活性代谢产物，包括一种具有高安全性和抗病毒活性的新型表面活性素以及一种强效抗氧化分子——白皮杉醇。这些代谢产物改变了病毒包膜内磷脂的结构和流动性，从而通过阻碍膜融合来抑制病毒进入。因此，NS12凭借其广谱抗病毒活性，为预防和控制呼吸道病毒感染提供了一种基于益生菌、环境可持续且非侵入性的抗病毒策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3df/12270477/4ac997672a62/research.0781.fig.010.jpg
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