Hegazy Alaa H A, Pérez-Quílez Olga, López-Muñoz Israel, Chamorro Anna, Abad Elena, San José Alba, Valera Júlia, Valerio Lluís, Soldevila Laura, Gorriz Ester, Herena Dolores, Fernández-Pedregal Elia, Llibre Josep M, Fernández-Rivas Gema, Cardona Pere Joan, Vallès Xavier, Roure Sílvia
Microbiology Department, Germans Trias i Pujol University Hospital, and Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Badalona, Spain.
Faculty of Medicine, University of Asyut, El Fateh, Egypt.
Open Forum Infect Dis. 2025 Jul 17;12(7):ofaf328. doi: 10.1093/ofid/ofaf328. eCollection 2025 Jul.
Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.
This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.
A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.
ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.
在非流行国家的长期移民中，输入性血吸虫病的诊断不足。目前缺乏用于诊断慢性血吸虫病的参考标准检测方法。
本研究评估了一种新的免疫层析（ICT）检测方法的敏感性和特异性，该方法使用血清（s）或即时护理手指针刺（FP）全血，针对来自撒哈拉以南非洲的长期移民的标准血清学检测方法。
共筛查了202人，平均年龄为42.7岁。其中，75.7%为男性，42.6%来自塞内加尔。ELISA检测阳性率为15.8%，ICT-p检测阳性率为24.3%，ICT-b（s）检测阳性率为46.5%，ICT-b（FP）检测阳性率为28.7%。所有检测与临床评分均显示出良好的一致性，但它们之间的一致性存在异质性。我们的结果表明ICT-b（s）具有更高的敏感性。治疗后的阳性反应表明所有检测方法都具有良好的特异性。
ICT-b（s）的敏感性高于其他标准检测方法。ICT-b（FP）策略可作为疑似慢性血吸虫病的第一步即时护理筛查工具。
