从印度尼西亚巴布亚一名发热患者身上提取的特定DNA。
sp. DNA recovered from a febrile patient from Papua, Indonesia.
作者信息
Johar Edison, Sriyani Ida Yus, Dewi Yora Permata, Puspitasari Agatha Mia, Nisa Fahira Ainun, Amalia Ristya, Kariodimedjo Pinkan Pertiwi, Poespoprodjo Jeanne Rini, Kenangalem Enny, Yudhaputri Frilasita Aisyah, Trianty Leily, Ledermann Jeremy P, Myint Khin Saw Aye, Mossel Eric C, Powers Ann M, Noviyanti Rintis
机构信息
Exeins Health Initiative, Jakarta, 12870, Indonesia.
Timika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, 99910, Indonesia.
出版信息
IDCases. 2025 Jun 25;41:e02298. doi: 10.1016/j.idcr.2025.e02298. eCollection 2025.
BACKGROUND
are neglected, arthropod-borne bacteria causing febrile illness of varying severity. Indonesia is endemic for several species, predominantly from murine and scrub typhus groups.
OBJECTIVE
We described here a potentially novel species in a young adult presenting with acute, undifferentiated, febrile illness at a primary health center in Timika, Papua, Indonesia, in 2021.
METHODS
Blood tested positive for spp. by a nucleic acid amplification test, 17-kDa and gene fragments were successfully sequenced.
RESULTS
The recovered sequences showed the highest similarity to two spp. of mosquito origin, with 90.0% identity for the 17-kDa and 85.6% for the gene.
CONCLUSION
These findings suggest the presence of a divergent lineage in Papua, Indonesia. To our knowledge, this is the first report of DNA sequences obtained from a human case in this region.
背景
节肢动物传播的细菌被忽视，可引起不同严重程度的发热性疾病。印度尼西亚有几种该类细菌为地方病，主要来自鼠型斑疹伤寒和恙虫病组。
目的
我们在此描述了2021年在印度尼西亚巴布亚省蒂米卡的一家初级卫生中心，一名患有急性、未分化发热性疾病的年轻成年人中发现的一种潜在新物种。
方法
通过核酸扩增试验检测血液中某菌属呈阳性，成功对17-kDa和某基因片段进行了测序。
结果
回收的序列与两种蚊子来源的某菌属相似度最高，17-kDa的同一性为90.0%，某基因的同一性为85.6%。
结论
这些发现表明在印度尼西亚巴布亚存在一个不同的菌系。据我们所知，这是该地区从人类病例中获得的该菌DNA序列的首次报告。
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