Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Denmark; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Denmark.
Environ Toxicol Pharmacol. 2023 Apr;99:104108. doi: 10.1016/j.etap.2023.104108. Epub 2023 Mar 13.
This study examines possible associations of maternal Persistent Organic Pollutants (POP) exposure during pregnancy, maternal hormone levels and fetal growth indices (FGI). During 1st trimester, we measured maternal thyroids, androgens and estrogens, lipophilic POP and perfluorinated-alkyl-acid (PFAA) levels in serum from nulliparous women. Adjusted multivariate-linear regression models assessed associations between exposure and outcomes. Maternal characteristics and POP exposures associated with maternal hormone levels. Lipophilic POP elicited inverse association with androgen and estrogen levels but no strong association with thyroids. Higher level of PFAA was associated with higher thyroid and androgen levels. The PFAA did not associate with estrogens. Higher thyroid-peroxidase-antibody (TPO-Ab) and estradiol level associated with higher birth weight and length in sons. For daughters, the TPO-Ab associations were the opposite being inversely associated with birth weight and length, and higher TPO-Ab and estradiol associated with lower gestational age. Mediation analyses suggested that TPO-Ab mediates the association of PFAA with FGI.
本研究探讨了孕妇怀孕期间持久性有机污染物（POP）暴露、母体激素水平和胎儿生长指数（FGI）之间可能存在的关联。在孕早期，我们从初产妇的血清中测量了甲状腺、雄激素和雌激素、亲脂性 POP 和全氟烷基酸（PFAA）水平。调整后的多元线性回归模型评估了暴露与结局之间的关联。母体特征和与母体激素水平相关的 POP 暴露。亲脂性 POP 与雄激素和雌激素水平呈负相关，但与甲状腺无明显关联。较高的 PFAA 水平与较高的甲状腺和雄激素水平相关。PFAA 与雌激素无关。较高的甲状腺过氧化物酶抗体（TPO-Ab）和雌二醇水平与儿子的出生体重和身长较高相关。对于女儿，TPO-Ab 的关联则相反，与出生体重和身长呈负相关，较高的 TPO-Ab 和雌二醇与较低的胎龄相关。中介分析表明，TPO-Ab 介导了 PFAA 与 FGI 的关联。
