Cai Ruisi, Yu Chenyi, Luo Xinyi, Xu Ningyu, Yu Jicheng, Ye Xiao, Zhang Yuqi, Gu Zhen
State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, School of Pharmacy, Zhejiang University, Hangzhou, 310058, China.
Pharmaceutical Sciences, Shandong University, Jinan, Shandong, 250012, China.
Adv Sci (Weinh). 2025 Aug;12(32):e05318. doi: 10.1002/advs.202505318. Epub 2025 Jul 18.
Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin-neuro-immune axis and inflammation-immune modulation. However, traditional acupuncture faces several limitations, such as its complex operation, the wide variety of acupoint combinations, long treatment durations, and susceptibility to individual differences between the practitioner and the patient. These challenges highlight the urgent need for intelligent medical devices that enable more precise and efficient modern acupuncture treatment. In response to this, this manuscript introduces engineered acupuncture needles (EANs) using techniques such as macroscopic mechanical etching, microscopic surface modification, and biomedical nanotechnology. These modified needles enhance acupuncture treatment by incorporating drug delivery, electrical stimulation, and thermal stimulation technologies. Here we provide an overview of recent advancements in EANs in terms of materials, fabrication methods, engineering technologies, acupoints, as well as disease models. The relevant bottlenecks and future prospects of their development are also discussed.
针灸作为一种在全球范围内应用的传统医学,被认为是治疗多种慢性疾病的有效方法。许多研究探索了针灸的生物学机制,包括皮肤-神经-免疫轴和炎症-免疫调节。然而,传统针灸面临着几个局限性,例如操作复杂、穴位组合繁多、治疗时间长以及从业者和患者之间易受个体差异影响。这些挑战凸显了对智能医疗设备的迫切需求,以实现更精确、高效的现代针灸治疗。对此,本手稿介绍了采用宏观机械蚀刻、微观表面改性和生物医学纳米技术等技术的工程化针灸针(EANs)。这些经过改性的针通过结合药物递送、电刺激和热刺激技术来增强针灸治疗效果。在此,我们从材料、制造方法、工程技术、穴位以及疾病模型等方面概述了EANs的最新进展。还讨论了其发展的相关瓶颈和未来前景。
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