De Silva M, Reeves J J
J Reprod Fertil. 1985 Nov;75(2):547-9. doi: 10.1530/jrf.0.0750547.
Indomethacin or saline was administered via intramuscular, intrauterine or intraovarian routes to dairy cows, within 24 h after standing oestrus was first observed. The incidence of ovulation was determined at slaughter. All of the saline-treated cows (18/18) ovulated. Ovulation was not blocked after intramuscular injection (0/6) or intrauterine infusion (0/6) of indomethacin. In all cows, ovulation was blocked after intraovarian injection (6/6) of indomethacin. These findings add support to the hypothesis that prostaglandins play an essential role in ovulation in the cow as in many other mammalian species.
在首次观察到静立发情后24小时内，通过肌肉注射、子宫内注射或卵巢内注射的方式给奶牛注射消炎痛或生理盐水。屠宰时测定排卵发生率。所有接受生理盐水处理的奶牛（18/18）均排卵。肌肉注射（0/6）或子宫内注入（0/6）消炎痛后排卵未受阻。在所有奶牛中，卵巢内注射（6/6）消炎痛后排卵受阻。这些发现进一步支持了这样一种假说，即与许多其他哺乳动物物种一样，前列腺素在奶牛排卵过程中起着至关重要的作用。
