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Cartilage Oligomeric Matrix Protein, a Potential Biomarker for Thoracic Aortic Dissection.

作者信息

Khachigian Levon M, Golledge Jonathan

机构信息

Vascular Biology and Translational Research, Department of Pathology, School of Biomedical Science, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.

Queensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Queensland, Australia; Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, Queensland, Australia.

出版信息

JACC Basic Transl Sci. 2025 Aug;10(8):101346. doi: 10.1016/j.jacbts.2025.101346. Epub 2025 Jul 25.

DOI:10.1016/j.jacbts.2025.101346
PMID:40714673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12314315/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/12314315/aad89c693eb7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/12314315/aad89c693eb7/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/12314315/aad89c693eb7/ga1.jpg

相似文献

1
Cartilage Oligomeric Matrix Protein, a Potential Biomarker for Thoracic Aortic Dissection.软骨寡聚基质蛋白，一种潜在的胸主动脉夹层生物标志物。
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2
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression.COMP的降低可作为主动脉夹层进展预警的预测指标。
JACC Basic Transl Sci. 2025 Jul 17;10(8):101329. doi: 10.1016/j.jacbts.2025.101329.
3
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease.ADAMTS4对软骨寡聚基质蛋白（COMP）的切割产生了一种与骨关节炎和其他形式的退行性关节疾病相关的新表位。
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本文引用的文献

1
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression.COMP的降低可作为主动脉夹层进展预警的预测指标。
JACC Basic Transl Sci. 2025 Jul 17;10(8):101329. doi: 10.1016/j.jacbts.2025.101329.
2
ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice.ADAMTS - 7缺乏可减轻小鼠胸主动脉瘤和主动脉夹层的发生。
J Mol Med (Berl). 2023 Mar;101(3):237-248. doi: 10.1007/s00109-023-02284-w. Epub 2023 Jan 20.
3
Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.
软骨寡聚基质蛋白是一种内源性β-arrestin-2 选择性变构调节剂，可拮抗 AT1 受体，对抗血管损伤。
Cell Res. 2021 Jul;31(7):773-790. doi: 10.1038/s41422-020-00464-8. Epub 2021 Jan 28.
4
Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models.诱导胸主动脉夹层：β-氨基丙腈相关小鼠模型的小型综述。
J Zhejiang Univ Sci B. 2020;21(8):603-610. doi: 10.1631/jzus.B2000022.
5
Upregulation of ADAMTS‑7 and downregulation of COMP are associated with aortic aneurysm.ADAMTS-7 的上调和 COMP 的下调与主动脉瘤有关。
Mol Med Rep. 2017 Oct;16(4):5459-5463. doi: 10.3892/mmr.2017.7293. Epub 2017 Aug 21.
6
Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification.miR-29 抑制介导的整合素和金属蛋白酶与血栓反应蛋白基序-7 的上调介导血管平滑肌钙化。
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2580-8. doi: 10.1161/ATVBAHA.112.300206. Epub 2012 Sep 20.
7
Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.软骨寡聚基质蛋白通过与 α7β1 整合素相互作用维持血管平滑肌细胞的收缩表型。
Circ Res. 2010 Feb 19;106(3):514-25. doi: 10.1161/CIRCRESAHA.109.202762. Epub 2009 Dec 17.
8
Acute aortic dissection.急性主动脉夹层
Lancet. 2008 Jul 5;372(9632):55-66. doi: 10.1016/S0140-6736(08)60994-0.
9
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.ADAMTS-7：一种直接结合并降解软骨寡聚基质蛋白的金属蛋白酶。
FASEB J. 2006 May;20(7):988-90. doi: 10.1096/fj.05-3877fje. Epub 2006 Apr 3.
10
Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.由于软骨寡聚基质蛋白基因突变导致的假性软骨发育不全和多发性骨骺发育不良。
Nat Genet. 1995 Jul;10(3):330-6. doi: 10.1038/ng0795-330.