Chen Peijian, Rao Xuejing, He Ping, Liu Jieting, Chu Yanhui, Dong Yan, Ding Minglu
College of Life Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, PR China; Heilongjiang Province Key Laboratory for Anti-fibrosis Biotherapy, Mudanjiang Medical University, No.3 Tongxiang Street, Mudanjiang, Heilongjiang 157011, PR China.
College of Life Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, PR China.
Biomed Pharmacother. 2025 Sep;190:118358. doi: 10.1016/j.biopha.2025.118358. Epub 2025 Jul 17.
Kidney diseases resulting from genetic predisposition, immune dysfunction, hypertension, diabetes, malignancies, hyperuricemia, and unhealthy lifestyle factors are garnering increasing attention due to the essential role of the kidney in maintaining systemic homeostasis. Quercetin (QCT), a polyhydroxy flavonoid abundantly present in the flowers, leaves, and fruits of numerous plants, including over 100 species of Chinese herbs such as Sophora japonica and Tansy, exhibits diverse biological activities and significant medicinal properties. These properties include antioxidant, anticancer, anti-inflammatory, antibacterial, antiviral, hypoglycemic, antihypertensive, immunomodulatory, and cardiovascular protective effects. QCT, generally recognized as safe, confers multiple health benefits, particularly in managing cardiovascular disorders, chronic bronchitis, hypertension, diabetes, and cancer. However, excessive intake may result in side effects. Notably, QCT has demonstrated efficacy in alleviating renal parenchymal injury and fibrosis, and it plays a pivotal role in treating diabetic nephropathy and cardiovascular diseases.
由于肾脏在维持全身稳态中起着至关重要的作用，由遗传易感性、免疫功能障碍、高血压、糖尿病、恶性肿瘤、高尿酸血症和不健康生活方式因素导致的肾脏疾病正受到越来越多的关注。槲皮素（QCT）是一种多羟基黄酮类化合物，大量存在于多种植物的花、叶和果实中，包括100多种中草药，如槐树和艾菊，具有多种生物活性和显著的药用特性。这些特性包括抗氧化、抗癌、抗炎、抗菌、抗病毒、降血糖、降血压、免疫调节和心血管保护作用。QCT通常被认为是安全的，具有多种健康益处，特别是在管理心血管疾病、慢性支气管炎、高血压、糖尿病和癌症方面。然而，过量摄入可能会导致副作用。值得注意的是，QCT已证明在减轻肾实质损伤和纤维化方面具有疗效，并且在治疗糖尿病肾病和心血管疾病中起着关键作用。
