Simon G L, Gelfand J A, Connolly R A, O'Donnell T F, Gorbach S L
J Trauma. 1985 Dec;25(12):1156-62.
Experimental Bacteroides fragilis bacteremia was studied in subhuman primates. Following intravenous infusion of viable B. fragilis there was an exponential clearance of organisms from the bloodstream. The major clearance organ was the liver, which accumulated 68.2% of the total inoculum. The most efficient clearance was exhibited by the spleen, with uptake of 1.16% gm tissue. Hemodynamic studies revealed no significant changes in heart rate, mean arterial pressure, or cardiac output following B. fragilis infusion. Complement activity as measured by CH50, alternative pathway hemolytic activity, granulocyte aggregometry, C4, C3, properdin, and Factor B levels were similarly unaffected by infusion of B. fragilis. In contrast, profound hemodynamic changes and a consistent decrease in complement activity was noted after challenge with S. minnesota. The results of this study suggest that B. fragilis bacteremia has a minor role in producing the acute hemodynamic changes associated with the septic shock syndrome.
在亚人类灵长类动物中研究了实验性脆弱拟杆菌菌血症。静脉输注活的脆弱拟杆菌后，血液中的细菌呈指数级清除。主要的清除器官是肝脏，其累积了总接种量的68.2%。脾脏表现出最有效的清除，每克组织摄取量为1.16%。血流动力学研究显示，输注脆弱拟杆菌后，心率、平均动脉压或心输出量无显著变化。用CH50、替代途径溶血活性、粒细胞聚集测定、C4、C3、备解素和B因子水平测量的补体活性同样不受脆弱拟杆菌输注的影响。相比之下，用明尼苏达沙门氏菌攻击后，观察到了深刻的血流动力学变化和补体活性持续下降。本研究结果表明，脆弱拟杆菌菌血症在产生与感染性休克综合征相关的急性血流动力学变化中作用较小。
