O'Donnell T F, Connolly R A, Gorbach S L, Tally F P
Surg Gynecol Obstet. 1980 Dec;151(6):735-9.
Results of this study show that an acute infusion of Bacteroides fragilis into a rabbit model is associated with a transitory and minimal lowering of mean arterial pressure. Peak left ventricular systolic pressure and its first derivative decreased significantly, but these abnormalities lasted for less than three minutes. By contrast, an infusion of Fusobacterium necrophorum is associated with a profound depression of mean arterial pressure, left ventricular systolic pressure and its first derivative, circulatory changes which are observed with a gram-negative aerobic infection. The lack of profound and permanent alterations in circulatory dynamics with the infusion of Bacteroides fragilis may be related to that organism's lack of classical endotoxin. While these studies were conducted in a nonprimate model, they should stimulate verification in a primate model. If validated, these results question the role of Bacteroides fragilis in producing septic shock.
本研究结果表明，向兔模型急性输注脆弱拟杆菌与平均动脉压短暂且轻微降低有关。左心室收缩压峰值及其一阶导数显著下降，但这些异常持续时间不到三分钟。相比之下，输注坏死梭杆菌会导致平均动脉压、左心室收缩压及其一阶导数显著降低，这些循环变化与革兰氏阴性需氧菌感染时观察到的情况相似。输注脆弱拟杆菌后循环动力学缺乏严重且永久性改变，可能与该菌缺乏典型内毒素有关。虽然这些研究是在非灵长类动物模型中进行的，但应促使在灵长类动物模型中进行验证。如果得到验证，这些结果对脆弱拟杆菌在引起感染性休克中的作用提出了质疑。
