Li Zhongshan, Jiang Rui, Qu Qi, Mou Shuanglin, Zhang Zheng, Zhu Wensheng
College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Department of Osteology, Huanggang Hospital of Traditional Chinese Medicine affiliated to Hubei University of Chinese Medicine, 19 Dongmen Road, Huanggang, 438000, China.
Aging Clin Exp Res. 2025 Jul 18;37(1):219. doi: 10.1007/s40520-025-03047-y.
Environmental pollution is widely acknowledged as a critical contributor to osteoporosis. Previous studies confirmed that heavy metal exposure is closely associated with decreased bone mineral density.
This study aimed to evaluate the relationship between cadmium (Cd) and the incidence of osteoporosis, and to explore the mediating role of inflammatory response and oxidative stress in the relationship.
We examined the relationship between blood Cd levels and osteoporosis risk using data from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013-2014 and 2017-2018, employing three statistical methods to evaluate these associations. Mediation analysis was conducted to investigate how inflammation and oxidative stress mediate Cd exposure-induced osteoporosis.
Among the 1290 individuals included in this study, 79 (6.12%) were diagnosed with osteoporosis. Our logistic regression analysis revealed a positive correlation between log10 Cd concentration and osteoporosis risk. Furthermore, heavy metal combinations showed a positive correlation with osteoporosis risk, with Cd identified as the primary factor in the Weighted Quantile Sum (WQS) and Bayesian Kernel Machine Regression (BKMR) models. Additionally, inflammation and oxidative stress acted as mediators in the correlation between Cd exposure and osteoporosis risk, accounting for 10.10% (OR: 0.002, 0.3, P = 0.042) and 4.06% (OR: 0.003, 0.11, P = 0.018) of the effect, respectively.
Our findings suggest that excessive Cd exposure increases osteoporosis risk, with inflammation and oxidative stress as key mediators. These results highlight the need for targeted strategies to reduce Cd exposure and protect bone health.
环境污染被广泛认为是骨质疏松症的一个关键促成因素。先前的研究证实，重金属暴露与骨密度降低密切相关。
本研究旨在评估镉（Cd）与骨质疏松症发病率之间的关系，并探讨炎症反应和氧化应激在该关系中的中介作用。
我们使用2013 - 2014年和2017 - 2018年进行的美国国家健康与营养检查调查（NHANES）的数据，研究血镉水平与骨质疏松症风险之间的关系，采用三种统计方法评估这些关联。进行中介分析以研究炎症和氧化应激如何介导镉暴露诱导的骨质疏松症。
本研究纳入的1290名个体中，79人（6.12%）被诊断为骨质疏松症。我们的逻辑回归分析显示，log10镉浓度与骨质疏松症风险呈正相关。此外，重金属组合与骨质疏松症风险呈正相关，在加权分位数和（WQS）模型以及贝叶斯核机器回归（BKMR）模型中，镉被确定为主要因素。此外，炎症和氧化应激在镉暴露与骨质疏松症风险的相关性中起中介作用，分别占效应的10.10%（OR：(0.002)，(0.3)，(P = 0.042)）和4.06%（OR：(0.003)，(0.11)，(P = 0.018)）。
我们的研究结果表明，过量镉暴露会增加骨质疏松症风险，炎症和氧化应激是关键中介因素。这些结果凸显了需要采取针对性策略来减少镉暴露并保护骨骼健康。
