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Multiple factors based adaptive laboratory evolution strategy enhances DHA production in Aurantiochytrium sp. PKU#Mn16 by rewiring key metabolic pathways.

作者信息

Ding Xueyan, Zhu Xingyu, Zhao Yuetong, Xie Ningdong, Wang Guangyi

机构信息

Center for Marine Environmental Ecology, School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, China.

Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, China.

出版信息

Microb Cell Fact. 2025 Jul 18;24(1):169. doi: 10.1186/s12934-025-02792-z.

DOI:10.1186/s12934-025-02792-z
PMID:40682034
Abstract
摘要

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1
Multiple factors based adaptive laboratory evolution strategy enhances DHA production in Aurantiochytrium sp. PKU#Mn16 by rewiring key metabolic pathways.基于多因素的适应性实验室进化策略通过重新连接关键代谢途径提高了 Aurantiochytrium sp. PKU#Mn16 中二十二碳六烯酸（DHA）的产量。
Microb Cell Fact. 2025 Jul 18;24(1):169. doi: 10.1186/s12934-025-02792-z.
2
Fed-batch fermentation of mixed carbon source significantly enhances the production of docosahexaenoic acid in Thraustochytriidae sp. PKU#Mn16 by differentially regulating fatty acids biosynthetic pathways.分批补料发酵混合碳源可通过差异调控脂肪酸生物合成途径显著提高多鞭毛藻 PKU#Mn16 中二十二碳六烯酸的产量。
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3
Transcriptomic Profiling and Gene Disruption Revealed that Two Genes Related to PUFAs/DHA Biosynthesis May be Essential for Cell Growth of Aurantiochytrium sp.转录组分析和基因敲除揭示，与多不饱和脂肪酸/DHA 生物合成相关的两个基因可能对金藻生长至关重要。
Mar Drugs. 2018 Sep 1;16(9):310. doi: 10.3390/md16090310.
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Low dissolved oxygen supply functions as a global regulator of the growth and metabolism of Aurantiochytrium sp. PKU#Mn16 in the early stages of docosahexaenoic acid fermentation.低溶解氧供应作为全球调节剂，在二十二碳六烯酸发酵的早期阶段，调控金藻烯醇酮 PKU#Mn16 的生长和代谢。
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Different nitrogen sources influence docosahexaenoic acid biosynthesis in marine heterotrophic protist Aurantiochytrium sp. PKU#SW8 by modulating central metabolic pathways.不同氮源通过调节中心代谢途径影响海洋异养原生生物金黄藻（Aurantiochytrium sp. PKU#SW8）中二十二碳六烯酸的生物合成。
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Efficient production of triacylglycerols rich in docosahexaenoic acid (DHA) by osmo-heterotrophic marine protists.通过渗透异养海洋原生生物高效生产富含二十二碳六烯酸（DHA）的三酰基甘油。
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Microorganisms. 2020 Apr 7;8(4):529. doi: 10.3390/microorganisms8040529.

本文引用的文献

1
Insights into the methodological perspectives for screening polyunsaturated fatty acids-containing bacteria.筛选含多不饱和脂肪酸细菌的方法学观点分析。
Arch Microbiol. 2024 Oct 9;206(11):429. doi: 10.1007/s00203-024-04155-5.
2
Selectively superior production of docosahexaenoic acid in Schizochytrium sp. through engineering the fatty acid biosynthetic pathways.通过改造脂肪酸生物合成途径在裂殖壶菌中选择性地高效生产二十二碳六烯酸。
Biotechnol Biofuels Bioprod. 2024 Jun 3;17(1):75. doi: 10.1186/s13068-024-02524-2.
3
Enhancing docosahexaenoic acid production from Schizochytrium sp. by using waste Pichia pastoris as nitrogen source based on two-stage feeding control.
利用废毕赤酵母作为氮源通过两段式补料控制提高裂殖壶菌中二十二碳六烯酸的产量。
Bioresour Technol. 2024 Jul;403:130891. doi: 10.1016/j.biortech.2024.130891. Epub 2024 May 23.
4
Dual stress factors adaptive evolution for high EPA production in Schizochytrium sp. and metabolomics mechanism analysis.双应激因子适应性进化提高裂殖壶菌中 EPA 的产量及其代谢组学机制分析。
Bioprocess Biosyst Eng. 2024 Jun;47(6):863-875. doi: 10.1007/s00449-024-03013-4. Epub 2024 Apr 30.
5
bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and HO stress response in Schizochytrium sp.bZIP 转录因子 FabR：调控裂殖壶菌中海藻油生物合成和 HO 应激反应的氧化还原依赖机制
Free Radic Biol Med. 2024 Jan;210:246-257. doi: 10.1016/j.freeradbiomed.2023.11.027. Epub 2023 Nov 30.
6
Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability.通过改进表达和遗传稳定性，重构聚酮基因簇的结构可提高解脂耶氏酵母中二十二碳六烯酸的产量。
Microb Cell Fact. 2023 Sep 29;22(1):199. doi: 10.1186/s12934-023-02209-9.
7
Bacterial acid stress response: from cellular changes to antibiotic tolerance and phenotypic heterogeneity.细菌酸应激反应：从细胞变化到抗生素耐受性及表型异质性
Curr Opin Microbiol. 2023 Oct;75:102367. doi: 10.1016/j.mib.2023.102367. Epub 2023 Aug 24.
8
Roles of Noncoding RNAs in Regulation of Mitochondrial Electron Transport Chain and Oxidative Phosphorylation.非编码 RNA 在调控线粒体电子传递链和氧化磷酸化中的作用。
Int J Mol Sci. 2023 May 28;24(11):9414. doi: 10.3390/ijms24119414.
9
Low dissolved oxygen supply functions as a global regulator of the growth and metabolism of Aurantiochytrium sp. PKU#Mn16 in the early stages of docosahexaenoic acid fermentation.低溶解氧供应作为全球调节剂，在二十二碳六烯酸发酵的早期阶段，调控金藻烯醇酮 PKU#Mn16 的生长和代谢。
Microb Cell Fact. 2023 Mar 15;22(1):52. doi: 10.1186/s12934-023-02054-w.
10
Propanol and 1, 3-propanediol enhance fatty acid accumulation synergistically in ATCC 20888.丙醇和1,3 - 丙二醇协同增强ATCC 20888中的脂肪酸积累。
Front Microbiol. 2023 Feb 9;13:1106265. doi: 10.3389/fmicb.2022.1106265. eCollection 2022.