Yabuuchi H, Ikeda T, Doi S, Tsujino G, Hiejima T, Shimotsuji T, Ashino N, Nishida M, Adachi K, Okuni H
Jpn J Antibiot. 1985 Jul;38(7):1721-38.
Cefotaxime (CTX) was administered to 130 children with various bacterial infections of 41 to 400 mg/kg/day for 2 to 21 days. The clinical effect of CTX was very satisfactory in respiratory tract infection, urinary tract infection and meningitis. The overall clinical effect was excellent in 59, good in 39, fair in 17 and failure in 8 with effective rate of 79.7%. During this therapy, side effects were seen in 3 cases, diarrhea in 1 and rash in 2. Abnormal laboratory findings were seen in 5 cases, elevation of GOT in 1, GOT, GPT and A1-P in 1, GOT, GPT and T. Bil. in 1, elevation of BUN, increase of number of basophils and albuminuria in 1 and observation of albuminuria in 1. The above results demonstrate that CTX is a clinically useful antibiotic for the therapy of pediatric infections.
将头孢噻肟（CTX）以每日41至400毫克/千克的剂量给予130名患有各种细菌感染的儿童，疗程为2至21天。CTX对呼吸道感染、尿路感染和脑膜炎的临床疗效非常令人满意。总体临床疗效为优59例，良39例，中17例，无效8例，有效率为79.7%。在该治疗过程中，3例出现副作用，1例腹泻，2例皮疹。5例实验室检查结果异常，1例谷草转氨酶（GOT）升高，1例GOT、谷丙转氨酶（GPT）和碱性磷酸酶（A1-P）升高，1例GOT、GPT和总胆红素（T. Bil.）升高，1例血尿素氮（BUN）升高、嗜碱性粒细胞数量增加和蛋白尿，1例观察到蛋白尿。上述结果表明，CTX是治疗小儿感染临床上有用的抗生素。
