Tsubakio T, Kanayama Y, Yonezawa T, Kitani T, Taniguchi N, Masaoka T, Shibata H, Horiuchi A, Hasegawa H, Kawagoe H
Jpn J Antibiot. 1983 Oct;36(10):2893-900.
Seventy-five patients with severe infection accompanying hematologic disorder, including leukemia and malignant lymphoma, were treated with cefotaxime (CTX). CTX was administered by intravenous drip infusion at a daily dose ranging from 4 to 16 g for terms of 3 to 21 days. The total doses were ranged from 12 to 226 g. The results obtained were as follows: Clinical effects: Excellent in 20 cases, good in 21 cases, fair in 7 cases and poor in 27 cases. The efficacy rate was 54.7% (41/75). Clinical effectiveness on isolated organisms (27 cases): In single infection (21 cases), the efficacy rates were 80% for Gram-positive cocci, including S. aureus and 63.6% for Gram-negative bacilli other than P. aeruginosa. In mixed infection (6 cases), the rate was 50.0%. There were no significant differences in the efficacy rates for those patients who were grouped by the initial number of neutrophil (less than 100, 101--500 and over 501/mm3). There were no significant difference in the efficacy rates for those patients who were grouped by the initial number of lymphocyte (less than 500 and over 501/mm3). Side effects and abnormal laboratory findings: One case of skin rash and 2 cases of elevated GOT and GPT were observed. CTX was therefore considered as a clinically useful antibiotic for the severe infections even in neutropenic state in patients suffering from malignant hematological diseases.
75例伴有血液系统疾病（包括白血病和恶性淋巴瘤）的严重感染患者接受了头孢噻肟（CTX）治疗。CTX通过静脉滴注给药，日剂量为4至16克，疗程为3至21天。总剂量为12至226克。结果如下：临床疗效：优20例，良21例，中7例，差27例。有效率为54.7%（41/75）。对分离出的病原菌的临床疗效（27例）：在单一感染（21例）中，对革兰氏阳性球菌（包括金黄色葡萄球菌）的有效率为80%，对除铜绿假单胞菌外的革兰氏阴性杆菌的有效率为63.6%。在混合感染（6例）中，有效率为50.0%。按中性粒细胞初始计数分组（小于100、101 - 500和大于501/mm³）的患者，其有效率无显著差异。按淋巴细胞初始计数分组（小于500和大于501/mm³）的患者，其有效率无显著差异。副作用及实验室检查异常：观察到1例皮疹，2例谷草转氨酶（GOT）和谷丙转氨酶（GPT）升高。因此，CTX被认为是一种对患有恶性血液病的中性粒细胞减少状态下的严重感染临床上有用的抗生素。
