Wakiguchi H, Maeda A, Ohara Y, Tone Y, Araki K, Shiraishi T, Ogura H, Kitamura I
Jpn J Antibiot. 1985 Jul;38(7):1925-30.
Clinical application to ascertain the effects of aspoxicillin (ASPC), a new semisynthetic penicillin antibiotic, upon several infectious diseases of children was performed in 7 cases with pneumonia, 5 cases with acute bronchitis, each case with tonsillitis, enterocolitis, urinary tract infection and suspected sepsis. ASPC was injected by drip infusion and the dosage was 63-117 mg/kg/day in 3 and 4 times a day. Clinical efficacy obtained as "excellent" was in 7 cases, "good" in 8 cases "poor" in 1 case, and efficacy rate was 93.8%. From the bacteriological point of view, eliminated in each of H. influenzae, H. parainfluenzae, group A beta-Streptococcus and unchanged in a case of E. coli. There were transient thrombocytopenia in 2 cases and eosinophilia in 3 cases.
对7例肺炎、5例急性支气管炎、各1例扁桃体炎、小肠结肠炎、尿路感染及疑似败血症患儿应用一种新型半合成青霉素抗生素阿扑西林（ASPC），以确定其对几种儿童传染病的疗效。阿扑西林采用静脉滴注给药，剂量为63 - 117毫克/千克/天，分3至4次给药。临床疗效评定为“优”的有7例，“良”的有8例，“差”的有1例，有效率为93.8%。从细菌学角度看，流感嗜血杆菌、副流感嗜血杆菌、A组β溶血性链球菌均被清除，1例大肠杆菌未发生变化。有2例出现短暂性血小板减少，3例出现嗜酸性粒细胞增多。
