吡啶甲酸乙酯对蜡状芽孢杆菌T生长抑制的研究
Study of inhibition of outgrowth in Bacillus cereus T by ethyl picolinate.
作者信息
Pandey N K, Gollakota K G
出版信息
Appl Environ Microbiol. 1977 May;33(5):1105-11. doi: 10.1128/aem.33.5.1105-1111.1977.
The effects of ethyl picolinate on germination, outgrowth, and sporulation of Bacillus cereus T were studied in a synthetic medium containing glucose. Ethyl picolinate specifically inhibited at two stages, outgrowth and sporulation. The initiation of germination and cell division was not affected. The inhibition of outgrowth by ethyl picolinate could be reversed by enrichment of inoculum with aspartic acid, asparagine, lysine, phenylalanine, and tyrosine among the amino acids and by oxalacetate. Nicotinic acid and nicotinamide also possessed this ability. Ethyl picolinate failed to block outgrowth when added to cultures incubated for a short time after inoculation. Enrichment of the medium with lysine plus zinc sulfate stimulated sporulation in the presence of ethyl picolinate to a significance degree.
在含有葡萄糖的合成培养基中研究了吡啶甲酸乙酯对蜡样芽孢杆菌T的萌发、生长和孢子形成的影响。吡啶甲酸乙酯在两个阶段特异性抑制，即生长和孢子形成。萌发和细胞分裂的起始不受影响。吡啶甲酸乙酯对生长的抑制作用可通过在氨基酸中用天冬氨酸、天冬酰胺、赖氨酸、苯丙氨酸和酪氨酸富集接种物以及用草酰乙酸来逆转。烟酸和烟酰胺也具有这种能力。接种后短时间培养的培养物中添加吡啶甲酸乙酯未能阻止生长。在吡啶甲酸乙酯存在下，用赖氨酸加硫酸锌富集培养基可显著刺激孢子形成。
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