Joseph Brice, Sultan Nessma, Jayash Soher Nagi
College of Medicine and Dentistry - Outreach Centre, Ulster University, Birmingham, UK.
Oral Biology department, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
BMC Oral Health. 2025 Jul 19;25(1):1221. doi: 10.1186/s12903-025-06487-0.
Silver nanoparticles (AgNPs) is a promising nanotechnological solution to prevent microbial colonization on dental implants, offering a promising avenue for combating implant-related infections and improving long-term treatment outcomes.
Using manual search and electronic databases such as PubMed Advanced Search and Google Scholar, a methodical search was carried out from 2013 to 2023 utilizing keywords, and inclusion and exclusion criteria to find pertinent papers addressing the research question "Can the use of silver nanoparticles in dental implants increase its antimicrobial potency?". Critical Appraisal analysis for this review was done using risk of bias tool for in vitro studies: QUIN tool.
Nine of the 122 articles that were retrieved underwent the three-step screening process before being chosen for the final analysis. QUIN Tool were used to evaluate the quality of the included in vitro studies. The summarized results from nine studies reveal the efficacy of AgNPs in inhibiting microorganisms and preventing biofilm formation on dental implants. In vitro tests demonstrate AgNPs' ability to hinder bacterial growth associated with peri-implantitis. Various techniques, including surface modifications and nanostructure incorporations, exhibit promising antibacterial effects.
AgNPs show promise in inhibiting multidrug-resistant bacteria, enhancing dental implant biocompatibility, and reducing peri-implant diseases, benefiting clinical outcomes and limiting bacterial colonization.
银纳米颗粒（AgNPs）是一种很有前景的纳米技术解决方案，可防止微生物在牙种植体上定植，为对抗种植体相关感染和改善长期治疗效果提供了一条有前途的途径。
通过手动检索以及PubMed高级搜索和谷歌学术等电子数据库，利用关键词以及纳入和排除标准，在2013年至2023年期间进行了系统的检索，以查找解决“在牙种植体中使用银纳米颗粒能否提高其抗菌效力？”这一研究问题的相关论文。本综述的批判性评价分析使用了体外研究的偏倚风险工具：QUIN工具。
检索到的122篇文章中有9篇在被选入最终分析之前经历了三步筛选过程。使用QUIN工具评估纳入的体外研究的质量。九项研究的总结结果揭示了AgNPs在抑制微生物和防止牙种植体上生物膜形成方面的功效。体外试验证明了AgNPs阻碍与种植体周围炎相关细菌生长的能力。包括表面改性和纳米结构掺入在内的各种技术都显示出有前景的抗菌效果。
AgNPs在抑制多重耐药菌、增强牙种植体生物相容性以及减少种植体周围疾病方面显示出前景，有利于临床结果并限制细菌定植。
