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抗生素在接受腕管松解术和扳机指松解术的糖尿病患者中是否有作用?723例病例的回顾性分析

Is There a Role for Antibiotics in Diabetic Patients Undergoing Carpal Tunnel and Trigger Finger Release? A Retrospective Analysis of 723 Cases.

作者信息

Arora Rohan, Azizi Armina, Audate Mitsy, Vonu Peter, Makarem Andres, Matthias Robert, Satteson Ellen

机构信息

University of Florida, Gainesville, USA.

出版信息

Hand (N Y). 2025 Jul 20:15589447251352004. doi: 10.1177/15589447251352004.

Abstract

BACKGROUND

This study aims to assess the role of perioperative antibiotic prophylaxis in surgical site infection (SSI) rates and other associated postoperative complications among diabetic patients undergoing carpal tunnel release (CTR) and trigger finger release (TFR) surgeries to address the gap in literature regarding the effectiveness of prophylactic antibiotics specifically in the diabetic population undergoing hand surgery.

METHODS

An institutional review board-approved retrospective review was performed to evaluate CTR or TFR performed in patients with diabetes between June 1, 2011, and June 1, 2021. Patients were identified using International Classification of Diseases, Tenth Revision codes for diabetes and Current Procedural Terminology codes for the surgeries of interest, with exclusions applied for certain prior conditions. The study focused on postoperative complications, particularly wound healing, examining variables such as demographics, outcomes, and perioperative antibiotic use.

RESULTS

The study found an overall postoperative complication rate of 13.9%, with SSIs being the most common. Despite the high prevalence of antibiotic prophylaxis use (82.1%), no significant reduction in postoperative complications or SSIs was observed. The study also examined the impact of glycemic control, body mass index (BMI), and comorbidities on surgical outcomes and found no linear association. However, diabetic patients with a BMI > 29 may have higher complication rates than those with a BMI ≤ 29.

CONCLUSIONS

The routine use of perioperative antibiotic prophylaxis does not significantly influence the rate of SSIs and associated postoperative complications in diabetic patients undergoing CTR and TFR. A more tailored approach to antibiotic use, considering individual patient factors beyond glycemic control, may be more appropriate in diabetic patients.

摘要

背景

本研究旨在评估围手术期抗生素预防在接受腕管松解术(CTR)和扳机指松解术(TFR)的糖尿病患者手术部位感染(SSI)发生率及其他相关术后并发症中的作用,以填补关于预防性抗生素有效性的文献空白,特别是在接受手部手术的糖尿病患者中。

方法

进行了一项经机构审查委员会批准的回顾性研究,以评估2011年6月1日至2021年6月1日期间糖尿病患者接受的CTR或TFR。使用国际疾病分类第十版糖尿病编码和感兴趣手术的当前手术操作术语编码识别患者,并排除某些先前存在的情况。该研究重点关注术后并发症,特别是伤口愈合情况,检查人口统计学、结局和围手术期抗生素使用等变量。

结果

研究发现总体术后并发症发生率为13.9%,其中SSI最为常见。尽管抗生素预防使用率很高(82.1%),但未观察到术后并发症或SSI有显著降低。该研究还检查了血糖控制、体重指数(BMI)和合并症对手术结局的影响,未发现线性关联。然而,BMI>29的糖尿病患者可能比BMI≤29的患者并发症发生率更高。

结论

围手术期常规使用抗生素预防对接受CTR和TFR的糖尿病患者的SSI发生率及相关术后并发症没有显著影响。对于糖尿病患者,考虑血糖控制以外的个体患者因素,采用更具针对性的抗生素使用方法可能更为合适。

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本文引用的文献

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Infections in patients with diabetes mellitus: A review of pathogenesis.糖尿病患者的感染:发病机制综述
Indian J Endocrinol Metab. 2012 Mar;16 Suppl 1(Suppl1):S27-36. doi: 10.4103/2230-8210.94253.

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