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心力衰竭患者与癌症患者的专科门诊姑息治疗比较:一项德国横断面研究。

Comparison of specialised outpatient palliative care in heart failure and cancer patients: a German cross-sectional study.

作者信息

Rottländer Dennis, Schmitz Marie-Therese, Grabenhorst Ulrich, Weckbecker Klaus, Just Johannes Maximilian

机构信息

Department of Cardiology, Krankenhaus Porz am Rhein, Koln, Germany

Cardiology, University Witten Herdecke Faculty of Health, Witten, Germany.

出版信息

BMJ Open. 2025 Jul 20;15(7):e096223. doi: 10.1136/bmjopen-2024-096223.

Abstract

OBJECTIVES

Specialised outpatient palliative care (SOPC) is an important element of the palliative care concept in Germany. The aim of this study is to compare patient characteristics, care processes and outcomes of patients with heart failure (HF) and oncological diseases, using the latter as a reference group to identify disease-specific needs and support the adaptation of SOPC to non-oncological conditions such as HF.

DESIGN, SETTING AND INTERVENTIONS: In this cross-sectional study (22 SOPC providers), clinical data of all palliative care patients who were treated between 2017 and 2021 were retrospectively analysed.

PRIMARY AND SECONDARY OUTCOME MEASURES

Survival was estimated by Kaplan-Meier analysis. To further examine the relationship between patient survival time and various variables, a Cox proportional hazards model was used. Differences in symptom burden were tested for statistical significance using the McNemar test.

PARTICIPANTS

Data from 48 882 patients were analysed, with 5387 (11.0%) identified as having a primary HF diagnosis. This cohort was compared against a large oncological group consisting of 34 287 (70.1%) patients.

RESULTS

For HF patients, the mean number of days spent in SOPC was 30.5±67.7 days and for oncological patients 44.1±72.0 days. A significantly higher proportion of oncological patients died in hospices (14.0%) and hospitals (6.9%) compared with HF (2.9% and 2.2%). Age-adjusted Charlson Comorbidity Index at admission into SOPC was 9.4±3.1 in oncological patients compared with 6.7±1.7 in HF (p<0.001). The median survival time (ie, time spent in last treatment episode) for patients with HF was only 10 days, whereas patients with oncological diagnoses had a median survival of 24 days.

CONCLUSIONS

HF patients in SOPC exhibit a different clinical profile compared with oncological patients, characterised by significant symptom burden and shorter survival times. These results emphasise the necessity for tailored palliative interventions to address the specific needs of HF patients.

摘要

目的

专科门诊姑息治疗(SOPC)是德国姑息治疗理念的重要组成部分。本研究旨在比较心力衰竭(HF)患者和肿瘤疾病患者的特征、护理过程及结果,以肿瘤疾病患者作为参照组,确定特定疾病需求,并支持SOPC适应诸如HF等非肿瘤疾病情况。

设计、设置与干预措施:在这项横断面研究中(22家SOPC服务机构),对2017年至2021年期间接受治疗的所有姑息治疗患者的临床数据进行回顾性分析。

主要和次要结局指标

采用Kaplan-Meier分析估计生存率。为进一步研究患者生存时间与各种变量之间的关系,使用了Cox比例风险模型。使用McNemar检验对症状负担差异进行统计学显著性检验。

参与者

分析了48882例患者的数据,其中5387例(11.0%)被确诊为原发性HF。将该队列与一个由34287例(70.1%)患者组成的大型肿瘤组进行比较。

结果

HF患者在SOPC的平均天数为30.5±67.7天,肿瘤患者为44.1±72.0天。与HF患者(2.9%和2.2%)相比,肿瘤患者在临终关怀机构(14.0%)和医院(6.9%)死亡的比例显著更高。SOPC入院时经年龄调整的Charlson合并症指数,肿瘤患者为9.4±3.1,而HF患者为6.7±1.7(p<0.001)。HF患者的中位生存时间(即最后治疗阶段的时间)仅为10天,而肿瘤诊断患者的中位生存期为24天。

结论

与肿瘤患者相比,SOPC中的HF患者表现出不同的临床特征,其特点是症状负担重且生存时间短。这些结果强调了针对HF患者的特定需求进行量身定制的姑息治疗干预的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c96/12278154/914c1f486619/bmjopen-15-7-g001.jpg

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