Kumar K Jagadish, Kundur Shivani, Bulusu Lalitha Vasudha, Nandish H R, Mehta Prisha
Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Indian J Pharmacol. 2025 Jul 1;57(4):273-275. doi: 10.4103/ijp.ijp_884_24. Epub 2025 Jul 21.
Metoclopramide is a dopamine-2 antagonist and is generally used as an antiemetic in clinical practice. Extrapyramidal reactions are the important adverse effects of metoclopramide which are reported in 0.2% of cases. In young children, the incidence can extend up to 25%. Metoclopramide-induced EPS include acute dystonia, tardive dyskinesia, parkinsonism, akathisia, and malignant neuroleptic syndrome. We are reporting a single dose of metoclopramide induced acute dystonia in an adolescent girl, which caused lot of anxiety in the patient and the parents which responded to oral diphenhydramine.
甲氧氯普胺是一种多巴胺 -2 拮抗剂，在临床实践中通常用作止吐药。锥体外系反应是甲氧氯普胺的重要不良反应，报告发生率为 0.2%。在幼儿中，发生率可高达 25%。甲氧氯普胺引起的锥体外系反应包括急性肌张力障碍、迟发性运动障碍、帕金森综合征、静坐不能和恶性精神抑制综合征。我们报告了一名青春期女孩单次服用甲氧氯普胺后诱发急性肌张力障碍的病例，这给患者及其父母带来了极大的焦虑，口服苯海拉明后症状得到缓解。
