Saleem Muhammad Zubair, Liu Tian, Song Ningjing, McReynolds Jayme, Gao Chen
Department of Pharmacology, Physiology and Neurobiology, University of Cincinnati, OH, United States of America.
J Mol Cell Cardiol Plus. 2025 Jul 1;13:100475. doi: 10.1016/j.jmccpl.2025.100475. eCollection 2025 Sep.
Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term recreational usage of cocaine on the heart have not been well studied. We established a short-term cocaine exposure rat model through self-administration, mimicking real-world recreational cocaine usage. Our results indicate that even such short-term cocaine usage induces deleterious effect on the heart including pathological remodeling and transcriptome reprogramming associated with major metabolic and contractile processes. This study sheds important insight on the molecular mechanisms of short-term exposure of cocaine-induced cardiovascular damage.
可卡因滥用仍然是一个重大风险，对心血管健康有深远的不利影响。虽然长期可卡因成瘾导致的心脏毒性已有充分记录，但可卡因短期娱乐性使用对心脏的潜在机制和分子影响尚未得到充分研究。我们通过自我给药建立了一个短期可卡因暴露大鼠模型，模拟现实世界中的可卡因娱乐性使用情况。我们的结果表明，即使是这种短期可卡因使用也会对心脏产生有害影响，包括与主要代谢和收缩过程相关的病理重塑和转录组重编程。这项研究为可卡因短期暴露诱导心血管损伤的分子机制提供了重要见解。
