Solberg L A, Strong J P, Holme I, Helgeland A, Hjermann I, Leren P, Mogensen S B
Lab Invest. 1985 Dec;53(6):648-55.
Coronary heart disease is strongly associated with the presence of stenosis in the epicardial coronary arteries. This prospective autopsy study shows that the relationship between risk factors for coronary heart disease and the occurrence of stenosis is the same as between risk factors and coronary atherosclerotic lesions: serum cholesterol, systolic and diastolic blood pressure contribute to formation of coronary stenosis; high density lipoprotein cholesterol is inversely related to stenosis. None of the other risk factors for coronary heart disease, such as fasting triglycerides, smoking habits, social class, and physical activity at work and at leisure, was statistically associated with the occurrence of coronary stenosis. Additional statistical analyses show that these selected risk factors do not seem to have any independent influence on the development of coronary stenosis over and above that of the extent of raised atherosclerotic lesions.
冠心病与心外膜冠状动脉狭窄密切相关。这项前瞻性尸检研究表明，冠心病危险因素与狭窄发生之间的关系，与危险因素和冠状动脉粥样硬化病变之间的关系相同：血清胆固醇、收缩压和舒张压促成冠状动脉狭窄的形成；高密度脂蛋白胆固醇与狭窄呈负相关。冠心病的其他危险因素，如空腹甘油三酯、吸烟习惯、社会阶层以及工作和休闲时的体力活动，均与冠状动脉狭窄的发生无统计学关联。进一步的统计分析表明，这些选定的危险因素，除了对动脉粥样硬化病变程度的影响之外，似乎对冠状动脉狭窄的发展没有任何独立影响。
