Kumar Rahul, Adeyemi Nurudeen Olatunbosun, Chattaraj Sourav, Alloun Wiem, Thamarsha A K A N W M R K, Anđelković Snežana, Mitra Debasis, Gautam Pankaj
Department of Microbiology, Graphic Era (Deemed to be University), 566/6, Bell Road, Clement Town, Dehradun, Uttarakhand 248002, India.
Department of Plant Physiology and Crop Production, Federal University of Agriculture, Alabata, Abeokuta, P.M.B.2240, Ogun State, Nigeria.
Sci One Health. 2025 Jun 28;4:100117. doi: 10.1016/j.soh.2025.100117. eCollection 2025.
Antimicrobial resistance (AMR) in is a major concern in terms of human health, environmental sustainability, and global food security. , the world's most prevalent foodborne pathogen, has gradually gained resistance to important drugs, complicating treatment efforts and leading to rising morbidity, mortality, and economic costs. Overuse of antibiotics in human medicine and agriculture, inadequate regulatory compliance, and environmental pollution from agricultural runoff and treated sewage all contribute to the growth and spread of AMR in . Health as well as viewpoints on environmental, animal, and human health will be required to address this complicated problem. This includes promoting reasonable antibiotic use, improving global surveillance systems, and researching novel treatments including phage therapy, probiotics, and new antibiotics. Proposals for vaccination and precise food safety standards are critical for limiting transmission across the food chain. Despite significant progress, critical research gaps continue, specifically in understanding the molecular basis of resistance and the role of environmental practices. However, contemporary research endeavors are concentrated on identifying and comprehending the prevalence of extensively drug-resistant strains, elucidating the bacterium's defense mechanisms against antibiotics, and investigating outbreaks associated with vegetables. Global surveillance, the development of alternative therapies, and the implementation of stricter antibiotic policies are essential strategies in addressing AMR in . Additionally, policy design and implementation, capacity building in low- and middle-income countries, and raising public awareness all necessitate urgent global collaboration among governments, international agencies, non-governmental organizations, and the corporate sector. Stricter regulations on overuse of antibiotics in agriculture is also called for. This review highlights the importance of multi-disciplinary struggles in engaging , as integrated resolutions through a One Health approach are crucial for ensuring food safety, preserving public health, and minimizing the worldwide threat of AMR.
在人类健康、环境可持续性和全球粮食安全方面，[病原体名称]的抗菌药物耐药性（AMR）是一个主要问题。[病原体名称]作为世界上最普遍的食源性病原体，已逐渐对重要药物产生耐药性，使治疗工作复杂化，并导致发病率、死亡率和经济成本上升。人类医学和农业中抗生素的过度使用、监管合规不足以及农业径流和处理后污水造成的环境污染，都促使[病原体名称]中AMR的增长和传播。需要采取健康以及关于环境、动物和人类健康的观点来解决这个复杂问题。这包括促进合理使用抗生素、改善全球监测系统以及研究包括噬菌体疗法、益生菌和新型抗生素在内的新治疗方法。疫苗接种建议和精确的食品安全标准对于限制[病原体名称]在食物链中的传播至关重要。尽管取得了重大进展，但关键的研究差距仍然存在，特别是在理解耐药性的分子基础和环境实践的作用方面。然而，当代研究工作集中在识别和理解广泛耐药[病原体名称]菌株的流行情况、阐明该细菌对抗生素的防御机制以及调查与蔬菜相关的疫情。全球监测、替代疗法的开发以及实施更严格的抗生素政策是应对[病原体名称]中AMR的重要策略。此外，政策设计和实施、低收入和中等收入国家的能力建设以及提高公众意识都需要政府、国际机构、非政府组织和企业部门之间进行紧急的全球合作。还需要对农业中抗生素的过度使用制定更严格的规定。本综述强调了多学科努力应对[病原体名称]的重要性，因为通过“同一健康”方法的综合解决方案对于确保食品安全、维护公众健康以及最小化AMR的全球威胁至关重要。
