Prakash U B, Luthra H S, Divertie M B
Mayo Clin Proc. 1985 Dec;60(12):813-21. doi: 10.1016/s0025-6196(12)64786-7.
A high frequency of occurrence of pleuropulmonary manifestations in mixed connective tissue disease (MCTD) has been reported in the literature. A retrospective analysis of 81 adult patients with the diagnosis of MCTD who were examined at our medical center from 1973 through 1977 revealed that pleuropulmonary involvement occurred in 20 (25%). Thirteen patients (16%) had dyspnea, six (7%) had chest pain, and four (5%) had cough. Chest roentgenograms disclosed basal interstitial processes in 15 patients (19%), pleural effusion in 5 (6%), pneumonic infiltrates in 3 (4%), and pleural thickening in 2 (2%). Abnormalities of pulmonary function were noted in 9 (69%) of 13 patients tested, and esophagographic abnormalities were present in 19 (53%) of 36 patients tested. Systemic corticosteroid therapy was beneficial in two of the eight patients so treated, and nonsteroidal anti-inflammatory drugs resolved most of the clinical features in four of the seven patients so treated. Six patients died during a 5-year follow-up period.
文献报道混合性结缔组织病（MCTD）中胸膜肺部表现的发生率较高。对1973年至1977年在我们医疗中心接受检查的81例诊断为MCTD的成年患者进行回顾性分析发现，20例（25%）出现胸膜肺部受累。13例患者（16%）有呼吸困难，6例（7%）有胸痛，4例（5%）有咳嗽。胸部X线片显示15例患者（19%）有基底间质病变，5例（6%）有胸腔积液，3例（4%）有肺炎浸润，2例（2%）有胸膜增厚。13例接受测试的患者中有9例（69%）肺功能异常，36例接受测试的患者中有19例（53%）食管造影异常。8例接受治疗的患者中有2例接受全身皮质类固醇治疗有效，7例接受治疗的患者中有4例使用非甾体抗炎药使大多数临床症状得到缓解。在5年随访期内有6例患者死亡。
