Li Yuan, Kawasaki Hiromi, Cui Zhengai, Nakaoka Sae
Division of Integrated Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, China.
PeerJ. 2025 Jun 30;13:e19699. doi: 10.7717/peerj.19699. eCollection 2025.
College students, particularly males, face a high risk of the human papillomavirus (HPV) infection, yet vaccination rates remain low in China. This study aims to explore the willingness to receive HPV vaccine among Chinese male medical college students based on health literacy (HL) theory and price sensitivity.
A cross-sectional survey was conducted from June 16 to July 16, 2024, to assess socioeconomic status and HL among college students at Guangdong Medical University. The survey was distributed via WeChat using convenience sampling through the Chinese online survey platform "Wenjuanxing" (http://www.wjx.cn). A Van Westendorp price sensitivity meter (PSM) was used to determine male medical college students' price sensitivity to HPV vaccines.
Among 1,631 valid participants, 59.4% ( = 969) expressed willingness to receive HPV vaccination. The key influencing factors included graduate status (OR: 1.82; 95% CI [1.00-3.32]; = 0.049), family history of cancer (OR: 1.29; 95% CI [1.01-1.66]; = 0.041), moderate daily exercise (OR: 53; 95% CI [1.21-192]; < 0.001), peers' HPV vaccination status (OR: 1.42; 95% CI [1.15-1.75]; < 0.001), and HL levels (OR: 1.03; 95% CI [1.01-1.05]; = 0.002). The Van Westendorp PSM analysis demonstrated high price sensitivity: the market price of the quadrivalent vaccine aligned closely with the lowest price point for male medical college students, whereas the nine-valent vaccine's market price exceeded the acceptable price range.
HL levels directly increased HPV vaccination intentions, and PSM analysis revealed the nine-valent vaccine's market price exceeded the acceptable price range, contrasting with the affordability-aligned quadrivalent vaccine. Interventions should prioritize HL programs and cost-reduction strategies (, subsidies for the nine-valent vaccine), while addressing nonprice barriers (including family history of cancer, moderate daily exercise and peer influence networks), particularly for the quadrivalent vaccine.
大学生，尤其是男性，面临着较高的人乳头瘤病毒（HPV）感染风险，但在中国，HPV疫苗接种率仍然很低。本研究旨在基于健康素养（HL）理论和价格敏感性，探讨中国男性医学生接种HPV疫苗的意愿。
于2024年6月16日至7月16日进行了一项横断面调查，以评估广东医科大学学生的社会经济状况和健康素养。该调查通过中国在线调查平台“问卷星”（http://www.wjx.cn），利用微信进行便利抽样分发。使用范·韦斯特恩多普价格敏感度测量仪（PSM）来确定男性医学生对HPV疫苗的价格敏感度。
在1631名有效参与者中，59.4%（n = 969）表示愿意接种HPV疫苗。关键影响因素包括毕业状态（OR：1.82；95%CI[1.00 - 3.32]；P = 0.049）、癌症家族史（OR：1.29；95%CI[1.01 - 1.66]；P = 0.041）、适度的日常锻炼（OR：1.53；95%CI[1.21 - 1.92]；P < 0.001）、同伴的HPV疫苗接种状况（OR：1.42；95%CI[1.15 - 1.75]；P < 0.001）以及健康素养水平（OR：1.03；95%CI[1.01 - 1.05]；P = 0.002）。范·韦斯特恩多普PSM分析显示出较高的价格敏感度：四价疫苗的市场价格与男性医学生的最低价格点密切相符，而九价疫苗的市场价格超出了可接受价格范围。
健康素养水平直接提高了HPV疫苗接种意愿，PSM分析显示九价疫苗的市场价格超出了可接受价格范围，这与价格可承受的四价疫苗形成对比。干预措施应优先考虑健康素养项目和降低成本策略（如九价疫苗补贴），同时解决非价格障碍（包括癌症家族史、适度的日常锻炼和同伴影响网络），特别是对于四价疫苗。
