Pírez Nicolás, Gascue Federico Andrés, Sorrentino Marcos Rafael, Locatelli Fernando Federico
Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología, Biología Molecular y Celular and CONICET-UBA, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina.
iScience. 2025 Jun 24;28(7):112999. doi: 10.1016/j.isci.2025.112999. eCollection 2025 Jul 18.
Sensory systems dynamically adjust their sensitivity to optimize information detection while minimizing interference. Sensory adaptation, a fundamental phenomenon across sensory modalities, temporarily reduces responsiveness during stimulus exposure and allows recovery afterward. We investigated how adaptation influences the perception of odor mixtures in honeybees, . Using electroantennogram recordings, we established conditions that reliably induce adaptation at the level of olfactory receptor neurons. We then examined its effects on mixture representation in projection neurons of the antennal lobe. Adaptation significantly reduced the contribution of the adapted odor while preserving the relative strength of the non-adapted component. A behavioral conditioning protocol revealed that adaptation shifted the perceptual quality of mixtures toward the non-adapted odor. Our findings demonstrate that sensory adaptation enhances mixture segregation, facilitating the detection of low-concentration components that might otherwise be masked within complex stimuli.
感觉系统会动态调整其敏感性，以优化信息检测，同时将干扰降至最低。感觉适应是一种跨感觉模态的基本现象，在刺激暴露期间会暂时降低反应性，并在之后恢复。我们研究了适应如何影响蜜蜂对气味混合物的感知。通过触角电图记录，我们建立了能在嗅觉受体神经元水平可靠诱导适应的条件。然后，我们研究了其对触角叶投射神经元中混合物表征的影响。适应显著降低了适应气味的贡献，同时保留了未适应成分的相对强度。一项行为条件反射实验表明，适应使混合物的感知质量向未适应气味偏移。我们的研究结果表明，感觉适应增强了混合物的分离，有助于检测低浓度成分，否则这些成分可能会被复杂刺激所掩盖。
