Florou Venetia A, Manaprasertsak Auraya, Slyusarenko Maria, Amend Sarah R, Kazi Julhash U, Hammarlund Emma U, Pienta Kenneth J
The Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Biochem Biophys Rep. 2025 Jul 5;43:102129. doi: 10.1016/j.bbrep.2025.102129. eCollection 2025 Sep.
Hair analysis has been used in the past as a method to explore environmental exposure to chemicals, toxins or drug ingestion, with wide applications in forensic science, environmental studies, anthropology and medicine. Although not a conventional sample type, hair offers significant advantages over traditional biospecimens, such as blood or urine. These include its stability, non-invasive nature and ease of collection and handling, as well as its ability to provide a "fossilized" record of a person's health or living conditions. These unique characteristics, along with advancements in analytical techniques have enabled hair analysis as a promising tool for the development of new biomarkers for both prognostic and diagnostic purposes in a range of medical conditions. The new developments in hair analysis add to its recognized diagnostic value in fields such as toxicology and pharmacology. In this review, we summarize recent data, ongoing developments and emerging possibilities of hair analysis as a scientific and diagnostic tool.
过去,头发分析一直被用作一种探索环境中化学物质、毒素暴露或药物摄入情况的方法,在法医学、环境研究、人类学和医学等领域有广泛应用。尽管头发不是传统的样本类型,但与血液或尿液等传统生物样本相比,它具有显著优势。这些优势包括其稳定性、非侵入性以及易于采集和处理,此外还能提供一个人健康状况或生活条件的“化石”记录。这些独特特性,再加上分析技术的进步,使头发分析成为开发一系列医疗状况预后和诊断新生物标志物的有前景的工具。头发分析的新进展增加了其在毒理学和药理学等领域已得到认可的诊断价值。在这篇综述中,我们总结了头发分析作为一种科学和诊断工具的最新数据、当前进展以及新出现的可能性。