Synergistic roles of NFATc1 and c-Jun in immunomodulation.

The immune system relies on precise regulatory mechanisms, with transcription factors being central to modulating immune responses. NFATc1 and c-Jun are key transcription factors that influence both adaptive and innate immunity. This review provides a comprehensive examination of the individual and synergistic roles of NFATc1 and c-Jun in immune regulation. We delve into their molecular mechanisms, regulatory pathways, and the latest experimental approaches used to study these interactions. Furthermore, we explore the therapeutic potential of targeting these transcription factors, highlighting their clinical implications in treating immune-related diseases. This analysis underscores the critical importance of NFATc1 and c-Jun, paving the way for innovative and better therapeutic strategies and future research in immune regulation research.